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Deutsches Krebsforschungszentrum (DKFZ)

Address Im Neuenheimer Feld 280
69120 Heidelberg
Deutschland

GERiT This institution in GERiT

69120 Heidelberg

Projects

Research Grants
- Current projects
  - Development and effectiveness evaluation of an interactive e-learning program to improve cancer patients' eHealth literacy (eHK-Strong).
    (Applicants Schulz, Holger ; Weg-Remers, Susanne ; Zapf, Antonia )
  - Dynamics of somatic mosaicism in the murine hematopoietic system
    (Applicants Gerbaulet, Alexander ; Höfer, Thomas )
- Completed projects
Clinical Research Units
- Completed projects
Priority Programmes
- Current projects
  - Role and regulation of subcellular membrane lipid peroxidation in ferroptosis
    (Applicant Dick, Tobias )
- Completed projects
Collaborative Research Centres
- Current projects
  - Molecular mechanism driving disulfide formation during FGF2 oligomerization and membrane translocation
    (Project Heads Dick, Tobias ; Nickel, Walter )
  - SFB 1129: Integrative Analysis of Pathogen – Replication and Spread
    (Spokesperson Kräusslich, Hans-Georg )
  - SFB 1324: Mechanisms and functions of Wnt signaling
    (Spokespersons Boutros, Michael ; Holstein, Thomas W. )
  - SFB 1366: Vascular Control of Organ Function
    (Spokesperson Augustin, Hellmut G. )
  - SFB 1389: Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)
    (Spokesperson Wick, Wolfgang )
  - SFB 1479: Oncogene-driven immune escape (OncoEscape)
    (Spokesperson Zeiser, Robert )
  - SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies
    (Spokesperson Hallek, Michael )
  - SFB 1550: Molecular Circuits of Heart Disease
    (Spokesperson Backs, Johannes )
  - SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
    (Spokesperson Eggert, Angelika )
  - SFB 1638: Cellular membrane remodelling – how changing form creates function
    (Spokesperson Meinecke, Michael )
  - Spatial and temporal coordination of RNA translation, replication and assembly in a membranous plus-strand RNA virus replication factory
    (Project Heads Bartenschlager, Ralf Friedrich Wilhelm ; Höfer, Thomas ; Rohr, Karl )
- Completed projects
  - Control of tumor-specific T cell responses through regulatory T cells
    (Project Heads Beckhove, Philipp ; Jäger, Dirk )
  - Control of Tumor Tolerance and Immunity by the Microenvironment
    (Project Heads Garbi, Natalio ; Hämmerling, Günter J. )
  - Development of a DNA vaccine against Schistosoma japonicum
    (Project Heads Ruppel, Andreas ; Schirrmacher, Volker )
  - Ectopic expression of tissiue-restricted antigens in human thymic epithelial cells: regulation and inter-.individual variations.
    (Project Head Kyewski, Bruno )
  - Ektopische Genexpression in Thymusepithelzellen: Bedeutung für T-Zell Toleranz und Autoimmunität
    (Project Head Kyewski, Bruno )
  - Fate mapping of hematopoietic stem cell activity under steady state and challenges
    (Project Heads Höfer, Thomas ; Rodewald, Hans-Reimer )
  - Flightless-1 as a redox sensor in immune cells
    (Project Head Dick, Tobias )
  - Functional characterization of a novel Wnt regulator in the central nervous system
    (Project Heads Niehrs, Ph.D., Christof ; Sirrenberg-Cruciat, Cristina-Maria )
  - Genetische Analysen zur Organogenese und Funktion des Thymus
    (Project Head Rodewald, Hans-Reimer )
  - Identified neuronal ensembles subserving spatial coding in the medial entorhinal cortex
    (Project Head Monyer, Hannah )
  - Induktion von Immunsuppression und peripherer Toleranz durch apoptotische Zellen
    (Project Head Krammer, Peter H. )
  - Integration of signal transduction and cytokine expression in T helper lymphocytes
    (Project Heads Höfer, Thomas ; Löhning, Max ; Radbruch, Andreas )
  - Intrinsic and microenvironment factors regulating the stem cell maintenance and the niche in normal and neoplastic epidermal cells
    (Project Head Boukamp, Petra )
  - Lipid activated nuclear receptors LXR? and ? in chronic fibrosing inflammation
    (Project Heads Gröne, Hermann-Josef ; Porubsky, Stefan )
  - Modulation of T Cell Reactivity by Tissue Cells
    (Project Head Arnold, Bernd )
  - Molecular analysis of glucocorticoid action underlying hippocampal neurogenesis and synaptic plasticity
    (Project Head Schütz, Günther )
  - Molecular mechanisms of DNA damage-induced cell fate decisions
    (Project Head Hofmann, Ph.D., Thomas G. )
  - Molecular mechanisms of protein thiol oxidation in peroxide sensing and stress signaling
    (Project Head Dick, Tobias )
  - Optimierung und Weiterentwicklung der 3D-Segmentierung sowie Integration in eine Open-Source Plattform zur Veröffentlichung der innerhalb des SFB erarbeiteten Erkenntnisse
    (Project Heads Meinzer, Hans-Peter ; Wolf, Ivo )
  - Oszillationen und Wellen in interagierenden Zellen
    (Project Heads Heinrich, Reinhart ; Höfer, Thomas )
  - Oxytocin in the prefrontal cortex: from neuromodulation of the local circuit to fear extinction
    (Project Head Grinevich, Valery )
  - Regulatory phosphorylation of scaffolding proteins of the inside-out-signaling complex
    (Project Heads Freund, Christian ; Höfer, Thomas )
  - Role of Dnmt3a2 in the establishment and stability of experience-dependent cell ensembles
    (Project Heads Allen, Kevin ; Oliveira, Ana M. M. )
  - SFB 405: Immune Tolerance and its Disturbances
    (Spokesperson Meuer, Stefan )
  - SFB 488: Molecular and Cellular Bases of Neural Development
    (Spokespersons Unsicker, Klaus ; Wittbrodt, Joachim )
  - SFB 618: Theoretical Biology: Robustness, Modularity and Evolutionary Design of Living Systems
    (Spokesperson Hammerstein, Peter )
  - SFB 636: Learning, Memory and Brain Plasticity: Implications for Psychopathology
    (Spokesperson Flor, Herta )
  - SFB 873: Maintenance and Differentiation of Stem Cells in Development und Disease
    (Spokespersons Ho, Anthony D. ; Lohmann, Jan )
  - SFB 938: Environment Specific Control of Immunological Reactivity
    (Spokesperson Meuer, Stefan )
  - SFB 1036: Cellular Surveillance and Damage Response
    (Spokesperson Bukau, Bernd )
  - SFB 1074: Experimental Models and Clinical Translation in Leukemia
    (Spokesperson Döhner, Hartmut )
  - SFB 1118: Reactive metabolites as a cause of diabetes complications
    (Spokespersons Herzig, Stephan ; Nawroth, Peter ; Szendrödi, Julia )
  - SFB 1134: Functional ensembles: cellular components, patterned activity and plasticity of co-active neurons in local networks
    (Spokesperson Draguhn, Andreas )
  - Stability and Violation of the Lymphoid and Myeloid Dichotomy in the Immune System
    (Project Head Rodewald, Hans-Reimer )
  - Surveillance of amino acid levels by mTORC1
    (Project Head Teleman, Aurelio A. )
  - The effect of IFNa signaling on hematopoietic stem cells
    (Project Head Essers, Marieke )
  - The effect of synaptic short-term plasticity on granule cell activity in the dentate gyrus microcircuit
    (Project Head von Engelhardt, Jakob )
  - The role of the nuclear receptor ´tailless´ in development and adult neural stem cells
    (Project Head Schütz, Günther )
  - Toleranzinduktion in peripheren T-Lymphozyten
    (Project Head Arnold, Bernd )
  - Transcriptional and epigenetic control by Sirtuins in response to stress
    (Project Heads Grummt, Ingrid ; Voit, Renate )
Research Fellowships
- Completed projects
CRC/Transregios
- Current projects
  - Metabolic switches regulating stress tolerance in eukaryotes
    (Project Heads Dick, Tobias ; Ralser, Markus )
  - Switching antigens by the exchange catalyst HLA-DM
    (Project Heads Freund, Christian ; Höfer, Thomas )
  - TRR 179: Determinants and dynamics of elimination versus persistence of hepatitis virus infection
    (Spokesperson Bartenschlager, Ralf Friedrich Wilhelm )
  - TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission
    (Spokespersons Freund, Christian ; Nickel, Walter )
  - TRR 319: RMaP: RNA Modification and Processing
    (Spokesperson Helm, Mark )
- Completed projects
  - Adaptive Photon Therapy in the Treatment of Lung and Liver Tumors
    (Project Heads Bendl, Rolf ; Combs, Stephanie ; Jäkel, Oliver ; Oelfke, Uwe ; Sterzing, Florian )
  - Biological and Time Adaptive Therapy of Pancreatic Carcinoma
    (Project Heads Bendl, Rolf ; Debus, Jürgen ; Jäkel, Oliver ; Oelfke, Uwe )
  - Chromatin structure and control of the rDNA locus
    (Project Head Grummt, Ingrid )
  - Identification and characterization of target genes for the Drosophila MBD2/3 protein
    (Project Head Lyko, Frank )
  - Impact of mast cell activation on T-helper polarization and adaptive immune responses in the skin
    (Project Heads Feyerabend, Thorsten ; Rodewald, Hans-Reimer )
  - Knowledge-based liver surgery
    (Project Heads Maier-Hein, Lena ; Mehrabi, Arianeb )
  - Knowledge-based multispectral tissue characterization
    (Project Head Maier-Hein, Klaus )
  - Knowledge-based reconstructive mitral valve surgery
    (Project Heads De Simone, Ph.D., Raffaele ; Wolf, Ivo )
  - Knowledge-Based Segmentation
    (Project Head Maier-Hein, Klaus )
  - MR-fingerprinting of the abdomen
    (Project Heads Hackert, Thilo ; Klauß, Miriam ; Laun, Frederik B. )
  - Non-coding RNAs in Hepatocellular Carcinoma
    (Project Head Diederichs, Sven )
  - Non-invasive assessment of tissue micro-morphology, vessel function and cell migration in vivo with contrast-enhanced MRI, VCT and hybrid imaging
    (Project Heads Bäuerle, Tobias ; Kiessling, Fabian ; Komljenovic, Dorde ; Müller, Margareta M. )
  - Quantitative studies of metabolism (F-18-deoxyglucose) and bone metabolism (F-18-fluoride) with dynamic positron emission tomography-computed tomography (dPET-CT)
    (Project Heads Dimitrakopoulou-Strauss, Antonia ; Goldschmidt, Hartmut ; Strauss, Ludwig Georg )
  - Regulation and function of the S100A8/S100A9 protein complex in inflammation-associated liver carcinogenesis
    (Project Heads Angel, Peter ; Heß, Jochen )
  - Regulation of homeostatic T cell proliferation
    (Project Head Schüler, Thomas )
  - Role of Junb and Junb target genes in vascular morphogenesis and homeostasis
    (Project Heads Angel, Peter ; Schorpp-Kistner, Marina )
  - Role of the Angiopoietin/Tie system in controlling vascular morphogenesis and homeostasis
    (Project Head Augustin, Hellmut G. )
  - The influence of bone substitute biomaterial on angiogenesis applied at bone defects caused by benign and malignant diseases
    (Project Heads Möhler, Thomas ; Schwartz-Albiez, Reinhard ; Willhauck-Fleckenstein, Martina )
  - The role of Notch ligands during blood vessel development
    (Project Head Fischer, Andreas )
  - The Role of Reactive Oxygen in chronic Liver Diseases
    (Project Heads Gülow, Karsten ; Krammer, Peter H. )
  - TRR 23: Vascular Differentiation and Remodelling
    (Spokespersons Augustin, Hellmut G. ; Plate, Karlheinz )
  - TRR 77: Liver Cancer - From Molecular Pathogenesis to Targeted Therapies
    (Spokesperson Schirmacher, Peter )
  - TRR 79: Materials for Tissue Regeneration within Systemically Altered Bone
    (Spokespersons Heiß, Christian ; Schnettler, Reinhard )
  - TRR 125: Cognition-Guided Surgery
    (Spokesperson Büchler, Markus W. )
  - TRR 209: Liver Cancer - New mechanistic and therapeutic concepts in a solid tumor model
    (Spokesperson Schirmacher, Peter )
  - TRR 240: Platelets – Molecular, cellular and systemic functions in health and disease
    (Spokesperson Nieswandt, Bernhard )
  - Tumor-Specific Vascular Reprogramming in HCC: Mechnisms and Therapeutic Targets
    (Project Heads Augustin, Hellmut G. ; Goerdt, Sergij )
Research Training Groups
- Current projects
  - GRK 2727: Innate Immune Checkpoints in Cancer and Tissue Damage (InCheck)
    (Spokesperson Cerwenka, Adelheid )
- Completed projects
  - GRK 214: 3D Tumor Diagnostics and Therapy Using Radiological Methods and Laser Medicine
    (Spokesperson Wannenmacher, Michael )
  - GRK 230: Molecular Cell Biology
    (Spokesperson Dobberstein, Bernhard )
  - GRK 268: Dynamics and Evolution of Cellular and Macromolecular Systems
    (Spokesperson Heinrich, Reinhart )
  - GRK 300: Pathogenic Microorganisms: Molecular Mechanisms and Genomic Approaches
    (Spokesperson Clayton, Christine Elizabeth )
  - GRK 388: Biotechnology: Biochemical and Molecular Foundation
    (Spokesperson Wink, Michael )
  - GRK 484: Signalling Systems and Gene Expression in Developmental Model Systems
    (Spokesperson Pollerberg, Gabriele Elisabeth )
  - GRK 793: Epidemiology of Communicable and Chronic Non-Communicable Diseases and their Interrelationship
    (Spokesperson Becher, Heiko )
  - GRK 886: Molecular imaging methods for the analysis of gene + protein expression
    (Spokesperson Gretz, Norbert )
  - GRK 1126: Development of New Computer-based Methods for the Future Working Environment in Visceral Surgery
    (Spokesperson Büchler, Markus W. )
  - GRK 1653: Spatio/Temporal Probabilistic Graphical Models and Applications in Image Analysis
    (Spokesperson Schnörr, Christoph )
  - GRK 2099: Hallmarks of Skin Cancer: Tumor Microenvironment and Melanoma Immunity
    (Spokesperson Goerdt, Sergij )
Major Instrumentation Initiatives
- Completed projects
  - MR-guided biologically individualized real-time adaptive high-precision radiotherapy (bio-iMRgRT)
    (Applicant Zips, Daniel )
Clusters of Excellence
- Completed projects
  - EXC 81: Cellular Networks: From Analysis of Molecular Mechanisms to a Quantitative Understanding of Complex Functions (CellNetworks)
    (Spokesperson Kräusslich, Hans-Georg )
Graduate Schools
- Completed projects
  - GSC 249: The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology
    (Spokesperson Wittbrodt, Joachim )
NFDI technical and methodological consortia
- Current projects
  - GHGA – German Human Genome-Phenome Archive
    (Spokesperson Stegle, Ph.D., Oliver )
  - National Research Data Infrastructure for Immunology
    (Spokesperson Busse, Christian )
  - NFDI4BIOIMAGE - National research data infrastructure for microscopy and bioimage analysis
    (Spokesperson Weidtkamp-Peters, Stefanie )
  - NFDI4Health – National Research Data Infrastructure for Personal Health Data
    (Spokesperson Fluck, Juliane )

Subinstitutions

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