Project Details

Professor Dr. Martin Eilers

Address Julius-Maximilians-Universität Würzburg
Biozentrum der Universität Würzburg
Lehrstuhl für Biochemie und Molekularbiologie
Am Hubland
97074 Würzburg

Projects

As Applicant
- Current projects
  - MYCN-dependent Transcription Termination and Stress Resilience of Transcription (Research Grants)
  - Multimerization of MYC proteins as oncogenic principle (Research Grants)
- Completed projects
  - Regulation of the cdk inhibitor, p27 Regulation des cdk inhibitor, p27 (Priority Programmes)
  - Rolle des Zink-Finger-Proteins Miz-1 in der Tumorigenese und in der Kontrolle der Proliferation von Keratinozyten und Lymphozyten (Research Grants)
  - Role of Miz1 in the Atr/Chk1 signalling pathway and in Myc-induced apoptosis (Research Units)
  - Systematic shRNA and siRNA screens to investigate drug resistance in human leukemia (Clinical Research Units)
  - Systemic shRNA screens and high throughout sequencing to investigate pathway dependence in multiple myeloma (Clinical Research Units)
  - Systematic shRNA screens for the analysis of critical signaling pathways in KRAS-mutant multiple myeloma (Clinical Research Units)
  - Myc-dependent apoptosis as a tumor-suppressive mechanism: how do cells discriminate between physiological and oncogenic levels of Myc expression? (Research Grants)
  - Targeting MYC in pancreatic cancer (Research Units)
  - ShRNA Screening and Histopathology (Research Units)
  - Targeting MYC-driven hepatocellular carcinoma via Aurora-A ligands (Research Units)
As Leader
- Completed projects
  - DNA-Sequenzer (Major Research Instrumentation)
  - "Laser Capture Microdissection" Mikroskop (Major Research Instrumentation)
  - Hochdurchsatz-Screening Mikroskop (Major Research Instrumentation)
  - automated high-content-fluorescence-microscope (Major Research Instrumentation)
  - Live-cell imaging microscope (Major Research Instrumentation)
  - 3-Laser Flow Cytometer (Major Research Instrumentation)
As Spokesperson
- Completed projects
  - TRR 17: Ras-dependent Pathways in Human Cancer (CRC/Transregios)
As Participating Researcher
- Current projects
  - GRK 2243: Understanding Ubiquitylation: From Molecular Mechanisms To Disease (Research Training Groups)
- Completed projects
  - GRK 767: Transcriptional Control in Developmental Processes (International Research Training Groups)
  - GSC 106: Graduate School for Life Sciences (GSLS) (Graduate Schools)
As Project Head
- Current projects
  - Engineering of CAR-T cells that overcome MYC-dependent immunosuppression in a genetically engineered mouse model of pancreatic cancer (CRC/Transregios)
  - The role of chromosome topology in MYCN function and neuroblastoma evolution and its potential for clinical exploitation (Collaborative Research Centres)
  - Role of premature transcription termination in colorectal tumorigenesis (CRC/Transregios)
- Completed projects
  - Rolle des Zink-Finger Proteins Miz-1 in der Transformation durch Myc und der Embryonalentwicklung der Maus (Collaborative Research Centres)
  - Mechanismus der Genaktivierung und -repression von Myc (Collaborative Research Centres)
  - Compartmentaion of Myc Degradation (Collaborative Research Centres)
  - Rolle von Myc und Miz1 in der Neurogenese im Zentralnervensystem (Collaborative Research Centres)
  - Role of FoxO proteins in oncogene co-operation (CRC/Transregios)
  - Role of the Myc/Miz1 interaction in the co-operation of Ras and Myc (CRC/Transregios)
  - Administration of the Transregio and Coordination of Activities (CRC/Transregios)
As Participating Person
- Completed projects
  - Functional genomic analysis of sorafenib resistance in human FLT3-ITD-positive AML (Clinical Research Units)

Servicenavigation

Hauptnavigation

Professor Dr. Martin Eilers

Additional Information

Servicenavigation

Hauptnavigation

Professor Dr. Martin Eilers

Additional Information

Textvergrößerung und Kontrastanpassung