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Institution
Universitätsklinikum Essen
Institut für Molekularbiologie
Address
Hufelandstraße 55
45147 Essen
Deutschland
GERiT
This institution in GERiT
45147 Essen
Projects
Research Grants
Current projects
Inhibition of SARS-CoV-2 infections of human lungs by functional inhibitors of the acid sphingomyelinase
(Applicants
Gulbins, Erich
;
Kamler, Markus
;
Krawczyk, Ph.D., Adalbert
)
Mechanisms and personalized treatment of depression-induced alcoholism
(Applicants
Gulbins, Erich
;
Kornhuber, Johannes
;
Müller, Ph.D., Christian P.
)
Molecular mechanisms of sphingosine-mediated killing of bacteria
(Applicant
Gulbins, Erich
)
Role of the acid ceramidase and sphingosine for the interplay of viral and bacterial pulmonary infections
(Applicant
Gulbins, Erich
)
Sphingosine inhalation as a novel treatment for bacterial pneumonia
(Applicants
Gulbins, Erich
;
Kamler, Markus
;
Taube, Christian
)
Completed projects
CCN3 (NOV): Key regulator promoting cell cycle exit and migration of trophoblast cells into the maternal compartment
(Applicant
Gellhaus, Alexandra
)
Die Bedeutung der Connexin26-Expression für den Implantationsvorgang durch Generieren von überlebenden Connexin26-defizienten Mäusen
(Applicant
Winterhager, Elke
)
Die CCN-Proteine CYR61 (CCN1) und NOV (CCN3): Regulatoren der Trophoblastinvasion
(Applicant
Winterhager, Elke
)
Die Interaktion von Connexin31 und AP-2gamma in der Trophoblast "lineage" Differenzierung für die Erhaltung des Stammzellpotenzials der Trophoblastzellen während der Plazentadifferenzierung
(Applicants
Schorle, Hubert
;
Winterhager, Elke
)
Experimentelle Tumortherapie durch Ceramid-vermittelte Amplifikation von Todesrezeptoren
(Applicant
Gulbins, Erich
)
Interaktion des Ad12 E1A12s-Tumorantigens mit dem PKA-Holoenzym: Ein neuer Mechanismus zur Aktivierung cAMP-induzierbarer Zielgene durch Adenoviren
(Applicant
Brockmann, Dieter
)
Interaktion von Connexin43 mit dem Wachstumsregulator NOV (CCN3)
(Applicant
Winterhager, Elke
)
Mechanisms and personalized treatment of depression-induced alcoholism
(Applicants
Gulbins, Erich
;
Kornhuber, Johannes
;
Müller, Ph.D., Christian P.
)
Molekulare Mechanismen der Aktivierung von T-Lymphozyten über den CD40-Liganden
(Applicant
Gulbins, Erich
)
Regulation of cell death by interaction of Bax with mitochondrial Kv1.3
(Applicant
Gulbins, Erich
)
Regulation of hematogenous ans lymph node tumor metastisis by acid sphingomyelinase
(Applicant
Gulbins, Erich
)
Regulation of the effects of antidepressants by sphingomyelin- and ceramide-controlled autophagy
(Applicants
Gulbins, Erich
;
Kornhuber, Johannes
)
Rolle der sauren Sphingomyelinase in Thrombozyten bei der Tumormetastasierung
(Applicant
Gulbins, Erich
)
Sphingolipide und bakterielle Infektionen
(Applicant
Gulbins, Erich
)
The acid sphingomyelinase/ceramide-hypothesis of major depression
(Applicants
Gulbins, Erich
;
Kornhuber, Johannes
)
Trophoblast stem cells: a model to investigate the role of Connexin31 for trophoblast differentiation
(Applicant
Winterhager, Elke
)
Priority Programmes
Completed projects
Central service project - Analysis and Synthesis of sphingolipids
(Applicant
Kleuser, Burkhard
)
Coordination project: Sphingolipids - Signals and Disease
(Applicant
Gulbins, Erich
)
Gfi1 in innate immunity: a downstream effector of Toll like receptor signaling and a novel regulator of endotoxin tolerance
(Applicant
Möröy, Tarik
)
Regulation of pulmonary inflammation in cystic fibrosis by ceramide
(Applicant
Gulbins, Erich
)
SPP 1267: Sphingolipids - Signals and Disease
(Spokesperson
Gulbins, Erich
)
The acid sphingomyelinase/ceramide hypothesis of major depression
(Applicants
Gulbins, Erich
;
Kornhuber, Johannes
)
Research Units
Completed projects
Coating of endotracheal tubes with sphingosine to prevent bacterial growth and ventilator-associated pneumonia
(Applicants
Gulbins, Erich
;
Seibel, Jürgen
)
FOR 2123: Sphingolipid Dynamics in Infection Control
(Spokesperson
Schneider-Schaulies, Sibylle
)
Role of neutral sphingomyelinase in mycobacterial infections
(Applicants
Grassmé, Heike
;
Gulbins, Erich
)
Role of the acid sphingomyelinase/ceramide system in lung edema induced by Staphylococcus aureus toxin
(Applicants
Fraunholz, Martin J.
;
Gulbins, Erich
)
Major Research Instrumentation
Completed projects
Feldemissions-Rasterelektronenmikroskop
Konfokales Laserscanning Mikroskop
Transmissionselektronenmikroskop
Research Training Groups
Completed projects
GRK 1045: Modulation of Host Cell Functions to Treat Viral and Bacterial Infections
(Spokesperson
Dittmer, Ulf
)
GRK 1739: Molecular Determinants of the Cellular Radiation Response and their Potential for Response Modulation
(Spokesperson
Jendrossek, Verena
)
GRK 2098: Biomedicine of the acid sphingomyelinase/acid ceramidase system
(Spokesperson
Gulbins, Erich
)
Additional Information
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