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Institution
Universitätsklinikum Carl Gustav Carus
an der Technischen Universität Dresden
Institut für Klinische Chemie und Laboratoriumsmedizin
Address
Fetscherstraße 74
01307 Dresden
Deutschland
GERiT
This institution in GERiT
01307 Dresden
Projects
Research Grants
Current projects
ADAM10 sheddase-mediated myeloid bias after acute myocardial infarction
(Applicants
El-Armouche, Ali
;
Klapproth, Erik
)
A novel regulator of metabolic disease
(Applicant
Alexaki, Vasileia Ismini
)
LIPID MEDIATORS IN STELLATE CELL ACTIVATION AND FIBROSIS DEVELOPMENT
(Applicants
Alexaki, Vasileia Ismini
;
Brosch, Mario
;
Fedorova, Maria
)
Role of UTX in the regulation of hematopoietic stem cell fate decisions during cell cycle progression.
(Applicant
Wielockx, Ph.D., Ben
)
The interplay between glutamine metabolism and epigenetics regulates prostate cancer stem cell populations and tumor radioresistance
(Applicants
Dubrovska, Anna
;
Mircetic, Ph.D., Jovan
;
Wielockx, Ph.D., Ben
)
Completed projects
Die Rolle von Junctional Adhesion Molecule-3 (JAM-3) als Counter-Rezeptor vom ß2-Integrin Mac-1 in entzündlichen Prozessen
(Applicant
Chavakis, Triantafyllos
)
Identification and characterisation of Krebs cycle gene mutations in endocrine tumours and beyond
(Applicants
Klink, Barbara
;
Richter, Ph.D., Susan
)
Regulation of microglia-mediated neuroinflammation by microneurotrophins
(Applicant
Alexaki, Vasileia Ismini
)
The impact of endothelial restricted hypoxia pathway proteins (PHD2 and endoglin) on the hematopoietic system and its bone marrow niche
(Applicant
Wielockx, Ph.D., Ben
)
The influence of HIF-prolyl hydroxylase-2 during colitis and inflammation-associated colorectal carcinogenesis in mice
(Applicant
Wielockx, Ph.D., Ben
)
The role of endothelial cell receptors and bacterial products in Staphylococcus aureus endovascular infection and novel strategies for anti-inflammatory interventions
(Applicant
Preissner, Klaus T.
)
The role of endothelial cell receptors and bacterial products in Staphylococcus aureus endovascular infection and novel strategies for anti-inflammatory interventions
(Applicant
Chavakis, Triantafyllos
)
Priority Programmes
Current projects
The impact of hypoxia pathway proteins in bone marrow niche cells during metastasis homing to bone
(Applicants
Rauner, Martina
;
Wielockx, Ph.D., Ben
)
Completed projects
Die Rolle von Endothelzell-Rezeptoren und bakteriellen Produkten in endovaskulären Infektionen vom S. aureus und neue Strategien zu anti-inflammatorischen Interventionen
(Applicant
Chavakis, Triantafyllos
)
The role of HIF prolyl hydroxylases in tumor progression and metastasis
(Applicant
Breier, Georg
)
Independent Junior Research Groups
Completed projects
The role of HIF prolyl hydroxylase-2 (PHD2) during physiological and pathological processes in mice
(Applicant
Wielockx, Ph.D., Ben
)
Reinhart Koselleck Projects
Completed projects
Neue potentielle zelluläre und molekulare Mechanismen, die zur Inflammation des adipösen Fettgewebes beitragen
(Applicant
Chavakis, Triantafyllos
)
Clinical Research Units
Completed projects
Central administration: analytical, clinical and model systems platforms
(Applicants
Bornstein, Ph.D., Stefan R.
;
Chavakis, Triantafyllos
;
Eisenhofer, Ph.D., Graeme
)
Dissecting the adrenal-endothelial-immune interface in systemic inflammation: Implications for inflammationrelated adrenal dysfunction
(Applicant
Chavakis, Triantafyllos
)
Genotype-steroidogenic phenotype relationships in patients with aldosteronomas and in experimental cell model systems
(Applicant
Lenders, Ph.D., Jacques W.M.
)
Hypoxia and MYC/MAX signaling pathways in chromaffin tumourigenesis
(Applicant
Eisenhofer, Ph.D., Graeme
)
KFO 252: Microenvironment of the Adrenal in Health and Disease
(Spokesperson
Bornstein, Ph.D., Stefan R.
)
Sonic hedgehog signalling in different forms of adrenal hyperplasia
(Applicants
Alexaki, Vasileia Ismini
;
Eaton, Suzanne
)
Heisenberg Professorships
Completed projects
HIF-pathway proteins during physiological and pathological processes in mice
(Applicant
Wielockx, Ph.D., Ben
)
Heisenberg Grants
Completed projects
The role of hypoxia pathway proteins in hematopoiesis and inflammation
(Applicant
Wielockx, Ph.D., Ben
)
Collaborative Research Centres
Completed projects
Developmental endothelial locus-1: A regulator of hematopoietic cell adhesion and function
(Project Head
Chavakis, Triantafyllos
)
Modulation der Immuntoleranz im Gefäßsystem durch Regulation der Leukozyten-Endothel-Interaktion
(Project Head
Chavakis, Triantafyllos
)
The immune-metabolic basis of the DEL-1/αvβ3 integrin-dependent induction of resolving macrophages in the resolution of inflammatory arthritis
(Project Head
Chavakis, Triantafyllos
)
Major Research Instrumentation
Completed projects
Flüssigchromatographie-gekoppeltes, hybrides Quadrupol-Flugzeitmassenspektrometer (LC-QTOF)
Flüssigkeitschromatographie-gekoppeltes Massenspektrometer (LC-MS/MS)
Spinning Disc - Intravitalmikroskop
Ultra-performance-liquid chromatography - coupled tandem mass spectrometry (UPLC-MS/MS)
CRC/Transregios
Current projects
Analytical platform
(Project Heads
Alves, Tiago
;
Bidlingmaier, Martin
;
Kurlbaum, Max
;
Peitzsch, Mirko
;
Walch, Axel Karl
)
Comprehensive characterization of patients with inflammatory bone disease with serological profiling and imaging
(Project Heads
Hofbauer, Lorenz C.
;
Mirtschink, Peter
;
Schett, Georg
;
Tsourdi, Elena
)
Defining the role of osteomorphs in inflammatory bone loss
(Project Heads
Hofbauer, Lorenz C.
;
Mirtschink, Peter
)
Dissecting the anti-tumour effects of trained neutrophils
(Project Head
Chavakis, Triantafyllos
)
HIF-MYC/MAX pathway in neural-crest derived catecholamine producing tumours: Identification of a metabolic fingerprint related to tumour aggressiveness
(Project Heads
Bechmann, Nicole
;
Eisenhofer, Ph.D., Graeme
;
Klink, Barbara
;
Lenders, Ph.D., Jacques W.M.
)
Immunometabolic regulation of adrenal glucocorticoid production and peripheral glucocorticoid signalling
(Project Heads
Alexaki, Vasileia Ismini
;
Eaton, Suzanne
;
Henneicke, Ph.D., Holger
)
Infrastructure for adrenal research
(Project Heads
Beuschlein, Felix
;
Eisenhofer, Ph.D., Graeme
;
Fassnacht, Martin
;
Müller-Pfefferkorn, Ralph
;
Reisch, Nicole
)
Innate immune training-mediated regulation of osteoclasts and inflammatory bone loss
(Project Heads
Chavakis, Triantafyllos
;
Kalafati, Ph.D., Lydia
)
Pathophysiology and advanced approaches for subtyping in primary aldosteronism
(Project Heads
Eisenhofer, Ph.D., Graeme
;
Lenders, Ph.D., Jacques W.M.
;
Williams, Ph.D., Tracy Ann
)
Patient cohorts and biobanks
(Project Heads
Eisenhofer, Ph.D., Graeme
;
Fassnacht, Martin
;
Pamporaki, Ph.D., Christina
;
Reincke, Martin
)
Regulatory mechanisms linking chronic gut inflammation and bone loss
(Project Heads
Wielockx, Ph.D., Ben
;
Zaiss, Mario M.
)
Targeting radio- and chemo-resistance in metastatic phaeochromocytoma/ paraganglioma
(Project Heads
Pietzsch, Jens
;
Richter, Ph.D., Susan
;
Ziegler, Ph.D., Christian G.
)
The impact of hypoxia pathway proteins on the adrenergic response in the adrenal gland and beyond
(Project Heads
Chavakis, Triantafyllos
;
El-Armouche, Ali
;
Wielockx, Ph.D., Ben
)
Completed projects
Analysis of inflammatory circuits during the Instant Blood-Mediated Inflammatory Reaction
(Project Heads
Chavakis, Triantafyllos
;
Ludwig, Barbara
;
Waskow, Claudia
)
Understanding the mechanisms leading to autoimmune adrenalitis by generating the first experimental animal model
(Project Head
Chavakis, Triantafyllos
)
Research Units
Current projects
FOR 2599: Tissue type 2 responses: Mechanisms of induction and regulation
(Spokesperson
Roers, Axel
)
Clusters of Excellence
Completed projects
EXC 168: Regenerative Therapies - From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration
(Spokespersons
Bonifacio, Ph.D., Ezio
;
Brand, Michael
;
Calegari, Ph.D., Federico
;
Tanaka, Ph.D., Elly Margaret
)
Additional Information
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