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Institution
Institut für Molekulare Biologie gGmbH
Address
Ackermannweg 4
55128 Mainz
Deutschland
GERiT
This institution in GERiT
55128 Mainz
Projects
Research Grants
Current projects
Alternative splicing of CD19 mRNA in pediatric leukemia and CART-19 therapy resistance - Regulators, genetic variants and cryptic isoforms
(Applicants
König, Ph.D., Julian
;
Legewie, Stefan
;
Zarnack, Katharina
)
At the intersection of DNA Replication and Genome integrity: Functional characterisation of the replicative helicase MCM2-7 during S-phase and replication stress.
(Applicant
Reuter, Luitpold Maximilian
)
Characterization of epigenetic regulators in Arabidopsis thaliana
(Applicant
Scheibe, Marion
)
Functions of replication clamp loading and modification in DNA damage tolerance
(Applicant
Ulrich, Ph.D., Helle
)
Identification and characterisation of novel piRNA processing factors in C. elegans
(Applicant
Ketting, Ph.D., René
)
Induction of a novel piRNA response in zebrafish
(Applicant
Ketting, Ph.D., René
)
Investigating the role of human topoisomerases in maintaining chromosome topology and preventing genomic instability
(Applicants
Papantonis, Argyris
;
Roukos, Vassilis
)
Mechanisms of Epigenetic Inheritance
(Applicant
Ketting, Ph.D., René
)
Mechanisms of replication fork-associated versus post-replicative bypass of abasic sites
(Applicant
Ulrich, Ph.D., Helle
)
Regulation of X chromosome dosage compensation by the protein SOA in Anopheles mosquitos
(Applicant
Keller Valsecchi, Ph.D., Claudia Isabelle
)
Completed projects
Biocomputing der Organisation von Chromatinstrukturen auf großen Längenskalen
(Applicant
Cremer, Christoph
)
Biogenese und Funktion von lichtsammelnden Chlorophyll-a/b-Komplexen
(Applicant
Paulsen, Harald
)
Biogenese und Funktion von wasserlöslichem Chlorophyll-Protein (WSCP)
(Applicant
Paulsen, Harald
)
Characterizing the gene regulatory circuitry of ST18 underlying neurogenesis
(Applicant
Garding, Angela
)
Electron-paramagnetic resonance (EPR) measurements for studying the assembly and structural dynamics of the light-harvesting chlorophyll a/b complex LHCII
(Applicant
Paulsen, Harald
)
Epigenetic Events in Nucleotide Excision Repair
(Applicant
Richly, Holger
)
Funktion der Ubiquitin-konjugierenden Enzyme RAD6 und UBC13/MMS2 in der postreplikativen DNA-Reparatur
(Applicant
Ulrich, Ph.D., Helle
)
Light-harvesting Chlorphyll-a/b Complex Immobilised on Solid Surfaces for Single-molecule Spectroscopy
(Applicant
Paulsen, Harald
)
Light Optical Nanoscopy of Cellular Structures using 4Pi-Microscopy - HighLight 2004
(Applicant
Cremer, Christoph
)
Molecular analysis of the regulation of cardiac IK1 current by protein kinase A and protein kinase C
(Applicant
Zitron, Edgar
)
Pigmentbindung an kleine Mitglieder der Chlorophyll-a/b-Protein-Familie
(Applicant
Paulsen, Harald
)
Regulation paternaler Vererbung eines Argonaute Proteins in C. elegans
(Applicant
Ketting, Ph.D., René
)
Targeted protein degradation – from small molecules to complex organelles
(Applicant
Beli, Petra
)
Ubiquitin-dependent and -independent functions of Myosin VI – Characterization of a molecular motor protein in DNA-replication and -repair and immune signaling
(Applicant
Wollscheid, Hans-Peter
)
Water-soluble chlorophyll protein (WSCP): Biological function, photophysics, and protein-directed assembly of nanoparticles
(Applicants
Basché, Thomas
;
Paulsen, Harald
)
Zeitaufgelöste Messungen zur Faltung und Pigmentbildung des Chlorophyll-a/b-Lichtsammlerproteins (LHCP)
(Applicant
Paulsen, Harald
)
Research Units
Current projects
Epigenetic regulation of the cellular homeostasis amid transcription-blocking DNA damage during development and aging
(Applicants
Schumacher, Björn
;
Wang, Ph.D., Siyao
)
FOR 2800: Chromosome Instability: Cross-talk of DNA replication stress and mitotic dysfunction
(Spokesperson
Bastians, Holger
)
FOR 5504: Physiological causes and consequences of genome instability
(Spokesperson
Schumacher, Björn
)
The role of R-loops in oncogene-induced replication stress and chromosomal instability
(Applicant
Beli, Petra
)
Completed projects
Combination of transcriptome-wide and structural approaches to study SHE binding to RNA localization elements in budding yeast
(Applicants
König, Ph.D., Julian
;
Niessing, Dierk
;
Zarnack, Katharina
)
FOR 2333: Macromolecular Complexes in mRNA translocation
(Spokesperson
Niessing, Dierk
)
Untersuchung dynamischer Prozesse und pathologischer Veränderungen in menschlichen Zellkernen mittels Axialtomographie und multispektraler Bildfolgenanalyse
(Applicant
Cremer, Christoph
)
Zentralprojekt
(Applicant
Jähne, Bernd
)
Priority Programmes
Current projects
Contributions of ubiquitin signaling to the maintenance of mitochondrial import channels
(Applicants
Methner, Axel
;
Ulrich, Ph.D., Helle
)
Completed projects
3D Analysis of Nuclear Nanostructures by Spatially Modulated Illumination Microscopy
(Applicant
Cremer, Christoph
)
Analysis of the 3D-nuclear-nanostructure in human Cells using Fluorescence Detection of Multiplex Dyes
(Applicant
Cremer, Christoph
)
Coordinator grant
(Applicant
Cremer, Christoph
)
Dissecting the role of chromosome genome organization in chromosome fragility and the formation of leukemia driving translocations.
(Applicant
Roukos, Vassilis
)
Mechanistic and functional characterization of Makorin 1 mRNPs
(Applicants
König, Ph.D., Julian
;
Roignant, Jean-Yves
;
Zarnack, Katharina
)
mRNP assembly at the 3' splice site studied by functional genomics and structural biology
(Applicants
König, Ph.D., Julian
;
Sattler, Michael
)
Optical accessibility analysis of macromolecule complexes to active/inactive chromatin regions studied by fluorescent beads in live cell nuclei
(Applicant
Cremer, Christoph
)
SPP 1128: Optical Analysis of the Structure and Dynamics of Supra Molecular Biological Complexes
(Spokesperson
Cremer, Christoph
)
Structure-function analysis of a novel, maternally provided, multi-functional RNP complex in C. elegans
(Applicant
Ketting, Ph.D., René
)
Threedimensional optical analysis of hypoxia inducible factor-1 (HIF-1) activated nuclear gene complexes by means of 2 P Confocal Laser Scanning and Spatially Modulated Illumination Nanoscopy, and 2P Spectral Precision Distance Microscopy
(Applicant
Cremer, Christoph
)
Independent Junior Research Groups
Current projects
From networks to mechanisms in health and disease
(Applicant
Luck, Katja
)
Completed projects
Investigating the function of atypical ubiquitylation in the DNA damage response
(Applicant
Beli, Petra
)
Heisenberg Grants
Current projects
Cracking the Molecular Code of Splicing and RNA Modifications
(Applicant
König, Ph.D., Julian
)
Scientific Networks
Current projects
JUICE Network: Junior Investigators in Chromatin & Epigenetics
(Applicant
Keller Valsecchi, Ph.D., Claudia Isabelle
)
Major Instrumentation Initiatives
Completed projects
FCS for Light Optical Nanoscopy of Cellular Structures using 4Pi-Microscopy - HighLight 2004
(Applicant
Cremer, Christoph
)
Collaborative Research Centres
Current projects
A Supramolecular Chemical Biology Approach to Studying Protein–RNA-Based Regulatory Switches
(Project Heads
Besenius, Pol
;
König, Ph.D., Julian
;
Schmid, Friederike
)
DNA-Facilitated Nano-assembly of Biological Block Co-polymers
(Project Heads
Girard, Martin
;
Lemke, Edward A.
;
Wittmann, Sina
)
Functions of RNA in double-strand break repair and DNA end protection
(Project Heads
Baumann, Ph.D., Peter
;
Luke, Ph.D., Brian
)
Functions of Ubiquitin and SUMO in Protein Phase Separation and Aggregation
(Project Heads
Kremer, Kurt
;
Kukharenko, Ph.D., Oleksandra
;
Ulrich, Ph.D., Helle
)
Genome-wide analysis of DNA damage, repair and replication stress
(Project Head
Ulrich, Ph.D., Helle
)
Integrated Research Training Group
(Project Heads
Dahm, Ralf
;
Niehrs, Ph.D., Christof
)
Integrated Research Training Group
(Project Heads
Bonn, Mischa
;
Dahm, Ralf
;
Dormann, Dorothee
)
Maintaining gene expression fidelity in response to DNA- and RNA-protein crosslinks
(Project Heads
Beli, Petra
;
Papantonis, Argyris
)
Mechanisms opposing genomic instability arising from dysregulated G4s and R-loops
(Project Head
Beli, Petra
)
Quantitative proteomics and integrated systems biology
(Project Heads
Behrends, Ph.D., Christian
;
Beli, Petra
;
Bhaskara, Ph.D., Ramachandra M.
;
Dikic, Ivan
;
Hummer, Gerhard
;
Münch, Christian
)
Regulation and Role of Physical Properties for Transcriptional Condensates
(Project Heads
Schick-Nickolaus, Sandra
;
Speck, Thomas
)
Service Project: Central management
(Project Head
Ulrich, Ph.D., Helle
)
Service project: Genomics & bioinformatics
(Project Heads
Karaulanov, Emil
;
Méndez-Lago, Maria
)
Service project: Quantitative proteomics
(Project Heads
Beli, Petra
;
Butter, Falk
;
Chen, Jiaxuan
)
SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis
(Spokespersons
Acker-Palmer, Amparo
;
Nitsch, Robert
)
SFB 1361: Regulation of DNA Repair and Genome Stability
(Spokesperson
Ulrich, Ph.D., Helle
)
Sources and consequences of intrinsic genomic instability across human cell types
(Project Heads
Roukos, Vassilis
;
Zarnack, Katharina
)
Support Project on Biopolymer Engineering and Bioanalytics
(Project Heads
Morsbach, Svenja
;
Möckel, Martin
)
Systematic investigation of the role of BAF complexes in genome stability
(Project Heads
Luck, Katja
;
Schick-Nickolaus, Sandra
)
Targeted Protein Degradation in Nuclear Quality Control Condensates
(Project Heads
Beli, Petra
;
Kremer, Kurt
;
Kukharenko, Ph.D., Oleksandra
;
Luck, Katja
)
Transposon-induced DNA damage in development and disease
(Project Head
Barau, Ph.D., Joan
)
Understanding the Specificity of the Subcellular Organization of Argonaute Proteins
(Project Heads
Ketting, Ph.D., René
;
Stelzl, Lukas
)
Visualization of Biopolymer Function and Research Data Management
(Project Heads
Hülsmann, Bastian B.
;
Ritz, Sandra
)
Completed projects
Autophagy in the cellular response to genotoxic stress
(Project Head
Beli, Petra
)
Deubiquitinating enzymes in selective autophagy
(Project Heads
Beli, Petra
;
Bremm, Anja
)
Puls-EPR-Abstandsmessungen zur Aufklärung von Assemblierung und Strukturdynamik eines selbstorganisierenden Biomolekülkomplexes
(Project Heads
Jeschke, Gunnar
;
Paulsen, Harald
)
Supramolecular structures of semiconductor nanocrystals, organic dye molecules, and biological light-harvesting complexes
(Project Heads
Basché, Thomas
;
Müllen, Klaus
;
Paulsen, Harald
)
Major Research Instrumentation
Completed projects
5-Laser Cell Sorter
Confocal Laser Scanning Microscope (CLSM) with Fluorescence Lifetime Imaging Microscopy (FLIM)
Durchflusszytometer
Fluorescence Microscope with Optical Tweezers and Microfluidic System
Großpartikel-Sortierer
High-resolution liquid chromatography mass spectrometry system
Hochgeschwindigkeitszellsortierer
NGS Sequencer
Spinning Disk Confocal Microscope
Research Fellowships
Completed projects
Biosynthese von Xanthophyllen in Grünalgen und Kieselalgen
(Applicant
Lohr, Martin
)
Functional analysis of the MCM2-7 DNA entry/exit gate during S-phase
(Applicant
Reuter, Luitpold Maximilian
)
CRC/Transregios
Current projects
Identification and processing of piRNA precursors in C. elegans
(Project Head
Ketting, Ph.D., René
)
Role of premature transcription termination in colorectal tumorigenesis
(Project Heads
Beli, Petra
;
Eilers, Martin
)
The mechanistic and functional impact of RNA modifications on alternative splicing
(Project Heads
Dieterich, Christoph
;
König, Ph.D., Julian
;
Roignant, Jean-Yves
)
Research Training Groups
Current projects
GRK 2526: GenEvo - Gene Regulation in Evolution: From Molecular to Extended Phenotypes
(Spokesperson
Foitzik, Susanne
)
GRK 2859: R-loop Regulation in Robustness and Resilience
(Spokesperson
Luke, Ph.D., Brian
)
Completed projects
GRK 214: 3D Tumor Diagnostics and Therapy Using Radiological Methods and Laser Medicine
(Spokesperson
Wannenmacher, Michael
)
GRK 886: Molecular imaging methods for the analysis of gene + protein expression
(Spokesperson
Gretz, Norbert
)
GRK 2015: Life Sciences, Life Writing: Boundary Experiences of Human Life between Biomedical Explanation and Lived Experience
(Spokesperson
Paul, Norbert W.
)
Graduate Schools
Completed projects
GSC 266: Materials Science in Mainz
(Spokesperson
Kläui, Mathias
)
Additional Information
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