Project Details

Professor Dr. Lorenz C. Hofbauer

Address Universitätsklinikum Carl Gustav Carus Dresden
Medizinische Klinik und Poliklinik III
Bereich Endokrinologie, Diabetes und Knochenstoffwechselerkrankungen
Fetscherstraße 74
01307 Dresden

Projects

As Applicant
- Current projects
  - Impact of iron and anemia on bone metabolism and fractures (Research Units)
  - Dissecting the bone cell-specific functions of ferroportin (Research Units)
  - Coordination Funds (Priority Programmes)
  - In vivo role of FLT3-CD45 signalling for bone remodelling (Research Grants)
- Completed projects
  - Regulation of osteoprotegerin ligand and osteoprotegerin production in human osteoblasts (Research Grants)
  - RANK-Ligand und Osteoprotegerin als Regulatoren des vaskulären und skeletalen Systems (Research Grants)
  - Rank-Ligand und Osteoprotegerin als gemeinsame Regulatoren des kardiovaskulären und skeletalen Systems (Heisenberg Fellowships)
  - Einfluss von Tyrosinkinase-Inhibitoren auf das wachsende Skelettsystem (Research Grants)
  - Interactions of the WNT and RANKL/OPG pathways in osteomimicry of prostate cancer (Research Units)
  - Central administration and tissue banking (Research Units)
  - Dissecting the osteoimmunological role of dickkopf-1 in arthritis and glucocorticoidinduced bone loss (Priority Programmes)
  - Role of Wnt5a in the interactions of prostate cancer cells and the bone microenvironment. (Research Units)
  - Central administration, tissue banking, and clinical translation. (Research Units)
  - Role of a Neuropilin-2/CXCR4 signaling pathway in the formation of prostate cancer bone metastases (Research Grants)
  - Role of Wnt signaling in classical and non-classical thyroid hormone actions (T0-T4) on bone (Priority Programmes)
  - The role of MAPK 38 in resistance of breast cancer and osteolytic bone metastases to inhibitors of the mevalonate pathway (Research Grants)
  - Novel biomarkers for bone metastases – from mechanism to analytics and back (Research Grants)
  - Dissecting the role of extracellular vesicles and their miRNA cargo in prostate cancer. From expression pattern to bone metastasis phenotype. (Priority Programmes)
As Spokesperson
- Completed projects
  - FOR 1586: SKELMET - Mesenchymal and Osteogenic Signalling Pathways in Malignant Bone Diseases (Research Units)
  - SPP 2084: µBONE: Colonization and interaction of tumor cells within the bone microenvironment (Priority Programmes)
As Participating Researcher
- Completed projects
  - EXC 168: Regenerative Therapies - From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration (Clusters of Excellence)
As Project Head
- Current projects
  - Defining the role of osteomorphs in inflammatory bone loss (CRC/Transregios)
  - Comprehensive characterization of patients with inflammatory bone disease with serological profiling and imaging (CRC/Transregios)
- Completed projects
  - Bone/Cartilage: Hard Tissue Replacement (DFG Research Centres)
  - Iron regulation of the hematopoietic stem and progenitor cell niche (Collaborative Research Centres)
  - Effects of sulfated glycosaminoglycans on bone regeneration through interactions with Wnt inhibitors (CRC/Transregios)
  - Sulfated glycoaminoglycans as coating for endoprostheses to improve osseointegration (CRC/Transregios)
As Participating Person
- Completed projects
  - Untersuchung des Knochenstoffwechsels in der HLA-B27-transgenen Ratte - einem Modell der ankylosierenden Sponyloarthritis (Research Grants)
  - Osteoklasten-assoziierter Rezeptor (OSCAR) als Bindeglied zwischen oxidativem Stress und Gefäßkalzifizierung (Research Grants)
  - Interplay between the Immune System and the Bone in the SWAP-70-/-mouse (Priority Programmes)

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Professor Dr. Lorenz C. Hofbauer

Additional Information

Servicenavigation

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Professor Dr. Lorenz C. Hofbauer

Additional Information

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