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Institution
Universitätsklinikum Aachen, AÖR
Klinik für Onkologie, Hämatologie und
Stammzelltransplantation (Med. Klinik IV)
Address
Pauwelsstraße 30
52074 Aachen
Deutschland
GERiT
This institution in GERiT
52074 Aachen
Projects
Research Grants
Current projects
Deep Learning-based Processing of Hematological Image-data (DELPHI)
(Applicants
Jost, Edgar
;
Merhof, Dorit
)
Dissecting the role of hypoxia-inducible factor (HIF)-regulated metabolic alterations in JAK2V617F, CALRdel52 and MPLW515L mutated myeloproliferative neoplasms (MPN)
(Applicant
Gezer, Deniz
)
Exploring the role of NADPH oxidase 2 (NOX2) in myeloproliferative neoplasms
(Applicant
Baumeister, Julian
)
Mapping the transcriptional and mutation landscape of the malignant hematopoietic clone in interaction with fibrosis-driving stromal cells in myeloproliferative neoplasms
(Applicant
Schneider-Kramann, Rebekka
)
Roles and targets of hematopoietic progenitor cell-reactive T cells in acquired aplastic anemia
(Applicants
Beier, Fabian
;
Hansmann, Leo Alexander
)
Completed projects
Charakterisierung genetischer Veränderungen im Rahmen der malignen Transformation von Telomerase-immortalisierten humanen Hepatozyten
(Applicant
Wege, Henning
)
Effect of BCR-ABL on self-renewal and differentiation of hematopoietic stem cells
(Applicant
Koschmieder, Steffen
)
Genexpression in Antigen-präsentierenden dendritischen Zellen
(Applicant
Zenke, Martin
)
Mechanisms of IFN-alpha induced biologic response, signaling, cellular context, drug synergism and clinical biomarkers in myeloproliferative neoplasms
(Applicant
Koschmieder, Steffen
)
Mediators of the Unfolded Protein Response defining therapeutic targets in acute myeloid leukemia (AML)
(Applicant
Schemionek-Reinders, Mirle
)
Reprogramming of and Programming by Mesenchymal Stem Cells (MSC)
(Applicant
Zenke, Martin
)
Role of Fc gamma RIIb signaling in CML stem cell biology and therapy resistance
(Applicant
Schemionek-Reinders, Mirle
)
Telomerbiologie und genetische Instabilität in der Krankheitsprogression der chronisch myeloischen Leukämie (CML)
(Applicants
Bokemeyer, Carsten
;
Steinemann, Doris
)
Research Fellowships
Completed projects
Funktionelle und strukturelle Charakterisierung des C/EBPalpha-Proteins: Auswirkungen von C/EBPalpha Genmutationen auf die DNA-Bindungsfähigkeit und Analyse von Interaktionen mit anderen Transkriptionsfaktoren
(Applicant
Koschmieder, Steffen
)
Influences of hypoxic conditions in the bone marrow concerning the behaviour and maintenance of chronic myeloid leukemic stem cells
(Applicant
Gezer, Deniz
)
Priority Programmes
Completed projects
Molecular analysis of gene expression in hematopoietic and neural stem cells, and functional analysis of stem cell genes.
(Applicant
Zenke, Martin
)
Reprogramming and somatic memory in ES cell/hematopoietic stem cell hybrids
(Applicant
Zenke, Martin
)
Clinical Research Units
Current projects
Coordination Funds
(Applicant
Koschmieder, Steffen
)
Dissecting the spatio-temporal dynamics of bone marrow fibrosis in MPN in response to therapy
(Applicants
Crysandt, Martina
;
Schneider-Kramann, Rebekka
)
Impact of Disease Burden and Timing of Disease Initiation on the Response to Interferonalpha (IFNa) in MPN-associated myelofibrosis
(Applicants
Hornef, Mathias Walter
;
Koschmieder, Steffen
)
Integrative platform for clinical and genomic data in Myeloproliferative Neoplasms (MPN)
(Applicants
Brümmendorf, Tim Henrik
;
Gesteira Costa Filho, Ivan
)
KFO 344: Untangling and Targeting Mechanisms of Myelofibrosis in Myeloproliferative Neoplasms (MPN)
(Spokesperson
Brümmendorf, Tim Henrik
)
Molecular targeting of STAT3-activating cytokines in the MPN pre-fibrotic niche
(Applicants
Müller-Newen, Gerhard
;
Schemionek-Reinders, Mirle
)
Targeting the bone marrow inflammatory niche in myelofibrosis with nanomedicine therapeutics
(Applicants
Chatain, Ph.D., Nicolas
;
Sofias, Alexandros Marios
)
Collaborative Research Centres
Completed projects
Funktionelle Analyse der replikativen Alterung humaner hämatopoetischer Stammzellen und neu identifizierter, Stammzellassoziierter Gene
(Project Heads
Brümmendorf, Tim Henrik
;
Heidenreich, Olaf
)
Genmodifizierte antigenpräsentierende dendritische Zellen für die Tumortherapie
(Project Heads
Pezzutto, Antonio
;
Zenke, Martin
)
Gentransfer in antigen-präsentierende dendritische Zellen
(Project Head
Zenke, Martin
)
The TGF-ß1/Id2/IRF8 signalling pathway in development of antigen presenting dendritic cells
(Project Head
Zenke, Martin
)
Major Research Instrumentation
Completed projects
TIRF Mikroskopiesystem
Research Units
Current projects
FOR 2690: Translational Pruritus Research
(Spokesperson
Schmelz, Martin
)
FOR 5659: TARGET-MPN: TARgetinG disease pErsisTence and progression of MyeloProliferative Neoplasms (MPN)
(Spokesperson
Heidel, Florian
)
Pruritus in Systemic Diseases
(Applicants
Koschmieder, Steffen
;
Kremer, Ph.D., Andreas Emanuel
;
Namer, Barbara
)
Targeting Kindlin-3-mediated integrin activation and signaling to eradicate persistent MPN clones
(Applicant
Koschmieder, Steffen
)
Completed projects
Vaskuläre dendritische Zellen in der Atherosklerose
(Applicant
Zernecke-Madsen, Alma
)
CRC/Transregios
Completed projects
Magnetische Polymer-Nanopartikel: Gentransfer/Drug delivery und Stammzelldifferenzierung kontrolliert durch magnetische Pol-Zeilen
(Project Heads
Rissing, Lutz
;
Steinhoff, Gustav
;
Zenke, Martin
)
Research Training Groups
Current projects
GRK 2375: Tumor-Targeted Drug Delivery
(Spokesperson
Kiessling, Fabian
)
Completed projects
GRK 426: Molecular Basis of Therapy
(Spokesperson
Birchmeier, Walter
)
International Research Training Groups
Completed projects
GRK 1508: Arterial Remodelling
(Spokesperson
Bernhagen, Jürgen
)
Additional Information
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