SPP 1937:  Innate Lymphoid Cells

• Subject Area: Medicine ; Biology
• Term: since 2016
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 273942223

The DFG priority program 1937 (SPP 1937) was established in 2016/2017 and aims to establish an interdisciplinary research program that comprehensively investigates the newly discovered family of ILC in humans and in mouse models. Our initiative aims to provide novel insights into ILC as guardians of tissue homeostasis and repair, in the defense against infections and in the pathogenesis of inflammation-driven diseases. These lines of research will continue to identify previously unappreciated functions of the immune system and will pave the way for the development of new treatment strategies in inflammation. Research on ILC has a strong interdisciplinary trajectory far beyond immunology, because it develops at the interface between the immune system and the biology of organ development, tissue homeostasis and repair. The program brings together immunologists, microbiologists, and clinical scientists such as gastroenterologists, rheumatologists and dermatologists as well as scientists interested in epithelial cell biology and experts in key technologies (single cell technology, microscopy, etc.) to accomplish these goals. The coordination proposal outlines the networking and coordinated efforts within SPP 1937.

• DFG Programme: Priority Programmes

Projects

• Analyzing the Heterogeneity of Innate Lymphoid Cells and the Relationship with their Microenvironments in situ and in vivo (Applicant Hauser, Anja Erika )
• Characterization of innate lymphoid cells under homeostatic and inflammatory conditions by epigenetic profiling (Applicants Flöß, Stefan ;  Lochner, Matthias )
• Characterization of phenotype and function of innate lymphoid cells in cutaneous leishmaniasis (Applicant von Stebut-Borschitz, Ruth Esther )
• Characterizing human ILC development from early hematopoietic progenitors: regulation by intrinsic and extrinsic signals (Applicant Uhrberg, Markus G. )
• Characterizing innate lymphoid cell homeostasis and function during caloric restriction (Applicant Jordan, Stefan )
• Coordination Funds (Applicant Diefenbach, Andreas )
• Cytokine-mediated regulation of ILC2 development and effector functions against gastrointestinal helminths (Applicant Vöhringer, David )
• Defining the bio-molecular features of pigment cell-specific NK cell memory (Applicant Wilhelm, Ph.D., Christoph )
• Defining the IL-7 niche for local and systemic ILC homeostasis (Applicant Schüler, Thomas )
• Design principles of NKp46+ ILC-macrophage cross-talk in autoimmune organ damage (Applicants Thurley, Kevin ;  Triantafyllopoulou, Antigoni )
• Epigenetic control of ILC3 plasticity (Applicant Diefenbach, Andreas )
• Evaluation of Innate Lymphoid Cell subsets and Aryl hydrocarbon Receptor-signaling in mouse models of liver damage and regeneration (Applicant Cerwenka, Adelheid )
• Innate lymphocytes in the female genital tract and their role in chlamydial infection (Applicant Häcker, Georg )
• Innate lymphoid cells in mouse and human leishmaniasis (Applicants Bogdan, Christian ;  Schleicher, Ulrike )
• Innate Lymphoid Cells induce a fibrotic phenotype of fibroblasts in fibrotic diseases (Applicant Ramming, Andreas )
• Interaction of Innate lymphoid cells with neurons in brain homeostasis and in Toxoplasma infection-induced neuroinflammation (Applicant Dunay, Ildikò Rita )
• Interplay of innate lymphoid cells and regulatory T cells in NLRP3 inflammasome-dependent nephritis (Applicant Ludwig-Portugall, Isis )
• Manipulation of ILC function and survival by human and simian immunodeficiency viruses (Applicant Kirchhoff, Frank )
• Mysm1 is a decision checkpoint regulator of Group2 innate lymphoid cell biology (Applicant Dürr, Claudia )
• Phenotype and function of innate lymphoid cells in cystic fibrosis lung disease (Applicant Dittrich, Anna-Maria )
• Regulation and Function of Autophagy in ILC2s (Applicant Tanriver, Yakup )
• Regulation of functional heterogeneity and plasticity of human tissue-bound ILC3 (Applicant Nattermann, Jacob )
• Role of Innate lymphoid cells (ILC) and aryl hydrocarbon receptor (AhR) during pulmonary bacterial infections (Applicant Romagnani, Ph.D., Chiara )
• Role of Innate Lymphoid Cells (ILC) in Solid Organ Transplantation (Applicant Kotsch, Ph.D., Katja )
• Role of the transcription factor c-Maf in controlling the development and function of RORgt+ type 3 innate lymphoid cells (Applicant Neumann, Christian )
• Role of type 2 innate lymphoid cells in immune-mediated liver disease and liver regeneration (Applicant Neumann, Katrin )
• The importance of lipid metabolism for the maintenance of pathogenic ILC2 responses (Applicant Wilhelm, Ph.D., Christoph )
• The neuropeptide neuromedin U promotes atopic dermatitis via stimulation of ILC2s (Applicant Klose, Christoph Siegfried Niki )
• The role of ILC3 in autoimmune inflammation (Applicant Waisman, Ari )
• The role of innate lymphoid cells (ILCs) in the modulation of Arthritis by intestinal helminthes (Applicant Zaiss, Mario M. )
• Tissue-niches and cellular interactions of mouse and human ILCs at single-cell resolution (Applicants Gasteiger, Georg ;  Grün, Dominic )
• Tissue-specific mechanisms of ILC2 adaptation and plasticity (Applicant Turner, Jan-Eric )

• Spokesperson: Professor Dr. Andreas Diefenbach