SPP 1629:  THYROID TRANS ACT - Translation of Thyroid Hormone Actions beyond Classical Concepts

• Subject Area: Medicine
• Term: from 2012 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 198800877

This Priority Programme aims at answering the question: What defines healthy and diseased thyroid function? To this aim, it will decipher the actions of thyroid hormones (TH) comprising T4 and T3 and novel, endogenous thyroid hormone (TH) derivatives such as T2 and thyronamines (from "T4-T0"). The Priority Programme will (1) establish a network and coordinate the efforts of leading thyroid research laboratories and centres in Germany. This interdisciplinary consortium will have the tools, expertise and energy to successfully lead thyroid research in Germany through the transition from findings in mouse models to better treatment options for patients. It will also internationally strengthen the position of German scientists in this field of research; (2) guide and streamline the interactions between basic and translational research labs that add knowledge of "T4-T0" in healthy as well as in the diseased thyroid state to clinical scientists with the overall goal to obtain options for better management of patients with disorders related to "T4-T0" malfunction; (3) provide for the recruitment and training of excellent junior scientists to foster a strong position of German science in this emerging field of research. A special focus of the Priority Programme is to promote and facilitate the return of leading German scientists in this field who are presently working abroad (brain gain); (4) launch and promote active and continued collaborative efforts and productive interactions with international thyroid research networks.

• DFG Programme: Priority Programmes
• International Connection: Belgium, USA

Projects

• Association of serum reverse triiodothyronine, diiodothyronine and thyronamine levels with cardiovascular risk factors and disorders (Applicant Völzke, Henry )
• Auto-regulation of the thyroid gland by classical and non-classical pathways (Applicant Brix, Klaudia )
• Biochemical and structural characterization of mammalian deiodinases as key regulators of thyroid hormone metabolism (Applicants Schweizer, Ulrich ;  Steegborn, Clemens )
• Biomarkers of Thyronamine Action (BioTAct) (Applicant Schomburg, Lutz )
• Cell type-specific inactivation of Mct8 in brain cells: Gene expression, metabolism, morphology (Applicant Wirth, Eva K. )
• Definition of central and cellular effects of thyroid hormones on white adipose tissue browning (Applicant Krause, Kerstin )
• Development of T3-peptide ligands to treat MCT8 deficiency via a Trojan horse like mechanism (Applicants Krude, Heiko ;  Tschöp, Matthias )
• Effects of thyronamines (TAM) and thyroacetic acid (TAC) metabolites on energy metabolism, mitochondrial function, Ca2+-signalling, plasma membrane action (Applicants Homuth, Georg ;  Köhrle, Josef )
• Identification of 3-iodothyronamine-induced signaling network in neuromodulation (Applicant Biebermann, Heike )
• Identification of pathways associated with thyroid hormones and their molecular regulators by integrated OMICs analyses of cross-sectional and longitudinal studies in the general population and selected patients (Applicant Völker, Uwe )
• Integrated-OMICs analyses to identify pathways associated with thyroid hormones and their molecular regulators: Screening for new markers to assess thyroid hormone action (Applicants Brabant, Georg ;  Friedrich, Nele ;  Führer-Sakel, Dagmar ;  Völker, Uwe )
• Molecular determinants of different thyroid hormone uptake/ efflux mechanisms for L-type amino acid transporter subtypes (Applicant Krause, Gerd )
• Molecular mechanisms of age-dependent thyroid hormone action on target tissues (Applicant Führer-Sakel, Dagmar )
• NAc-3-T1AM: a novel hormone connecting thyroid and cardiovascular function (Applicant Schomburg, Lutz )
• Non Classical Concepts of Thyroid Hormone Action in the Regulation of Body Temperature (Applicant Mittag, Jens )
• Non-classical thyroid hormone action mediated by thyroid hormone receptor alpha and beta (Applicant Möller, Lars )
• Oral thyroxine resistance revisited - how thyroxine transpasses the gut-blood barrier (Applicants Führer-Sakel, Dagmar ;  Schweizer, Ulrich )
• Plasma membrane-mediated non-genomic effects of T4, T3 and thyroid hormone metabolite tetrac on different aspects of mesenchymal stem cell biology and their signaling pathways (Applicants Nelson, Peter Jon ;  Spitzweg, Christine )
• ROLE OF TANYCYTES IN THE NON-CLASSICAL FEEDBACK REGULATION OF THE HYPOTHALAMIC-PITUITARY-THYROID AXIS (Applicant Müller-Fielitz, Helge )
• Role of the murine thyroid hormone transporters Mct8 and Oatp1c1 in skeletal muscle, cardiovascular and metabolic system (Applicants Heuer, Heike ;  Mittag, Jens )
• Role of Tight Junctions in Gallstone Formation under Hypothyroidism (Applicant Zwanziger, Denise )
• Role of Wnt signaling in classical and non-classical thyroid hormone actions (T0-T4) on bone (Applicants Hofbauer, Lorenz C. ;  Rauner, Martina )
• SPP1629 coordination project (Applicants Biebermann, Heike ;  Brix, Klaudia ;  Führer-Sakel, Dagmar )
• Structure and function of the thyroid hormone transporter MCT8 (Applicant Schweizer, Ulrich )
• The influence of thyroid hormones, receptors, and transporters on brain structure and function (Applicants Brabant, Georg ;  Münte, Thomas F. ;  Sartorius, Alexander )
• The relevance of thyroid hormones for the transdifferentiation of white into brown adipose tissue (Applicant Tönjes, Anke )
• The tissue-specific role of the murine thyroid hormone transporters Mct8 and Mct10 (Applicant Heuer, Heike )
• Trace amine-associated receptors (TAAR) as targets for thyronamines (Applicant Stäubert, Claudia )
• Unraveling the molecular basis for successful thyroid hormone replacement therapy (Applicants Brabant, Georg ;  Mittag, Jens )
• Z-Project: Analytical procedures for the determination of the thyroid hormone status in biological samples collected in the framework of the priority programme SPP 1629 (Applicant Köhrle, Josef )

• Spokesperson: Professorin Dr. Dagmar Führer-Sakel