SFB 456:  Target Structures for Selective Tumor Interventions

• Subject Area: Medicine
• Term: from 1999 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5483209

The collaborative research centre 456 aims at the identification of selective target structures for efficient interference with tumorogenesis and tumor progression, with special emphasis on gynaecological, intestinal and haematologic tumors. A major interest lies in the prevention of tumor evasion, focussing on cell adhesion, micrometastasis and the development of gentherapeutic approaches. In addition, immunotherapeutical strategies are developed which intend to specifically enhance presentation of tumor-associated antigens and expansion of tumor-specific T cells. The collaborative researach centre 456 represents an important infrastructure as a centre of translational medicine in the field of oncology.

• DFG Programme: Collaborative Research Centres
• International Connection: USA

Completed projects

• A1 - Rolle der CGRP-Rezeptorunterheinheit CATS (mRAMP-1) bei Tumorzell-Stroma-Interaktionen und Metastasierung (Project Head Holzmann, Bernhard )
• A02 - "Tumor-associated signalling molecules as molecular targets of multi-modal therapies in gastric cancer" (Project Heads Höfler, Heinz ;  Luber, Birgit )
• A3 - Funktion des Tumor-assoziierten T1-Rezeptors im invasiven Mammakarzinom (Project Head Werenskiold, Anne Katrin )
• A4 - Molekularbiologische Untersuchungen zur Pathogense des Plattenepithelkarzinoms (Project Heads Balling, Ph.D., Rudi ;  Höfler, Heinz )
• A05 - Tumor- und Metastasen-initiierende Mutationen beim Mammakarzinom: Identifizierung des abhängigen Phänotyps als Ausgangspunkt für adjuvante Therapien (Project Head Klein, Christoph )
• A7 - Molekulardiagnostische und funktionelle Untersuchungen zur Bedeutung von Phosphotyrosinphosphatasen für Wachstum und Metastasierung des Mammakarzinoms (Project Heads Ullrich, Axel ;  Wallasch, Christian )
• A8 - Diagnostische Strategien zum Monitoring gentharapeutischer Interventionen (Project Heads Anton, Martina ;  Avril, Norbert ;  Haubner, Roland )
• A9 - Nichtviraler rezeptorvermittelter Gentransfer zur Inhibierung von Tumorausbreitung und Metastasierung (Project Heads Plank, Christian ;  Schmitt, Manfred )
• A10 - Entwicklung neuer selektiver Inhibitoren für INtegrine und ihr Einsatz in der Krebstherapie (Project Heads Kessler, Horst ;  Schmidt, Eva-Kathrin ;  Schmitt, Manfred )
• A13 - "SASH1: a member of the SLY-family as a candidate tumor suppressor in co-lorectal cancer" (Project Heads Holzmann, Bernhard ;  Janssen, Klaus-Peter )
• A14 - The role of histone deacetylases for the development and as targets for ther-apy of intestinal tumours (Project Head Göttlicher, Martin )
• A15 - The IKK-NF-KappaB signalpathways as molecular target of the pancreas carcinome (Project Heads Schmid, Roland M. ;  Schneider, Günter )
• A16 - Cell Cycle Regulation at the G2/M transition (Project Head Duyster, Justus )
• A17 - Mechanisms of aberrant NF-kappaB Activation in Diffuse Large B Cell Lymphoma (Project Head Ruland, Jürgen )
• A18 - IKKâ in macrophages and its role on tumor promotion and progression (Project Head Greten, Florian R. )
• B1 - Diagnostische Strategien zum Monitoring gentherapeutischer Interventionen (Project Heads Avril, Norbert ;  Hantzopoulos, A. Petros ;  Haubner, Roland )
• B02 - Interaction of primitive hematopoietic stem/progenitor cells with the stromal microenvironment in normal and leukemic hematopoiesis (Project Heads Götze, Katharina Simone ;  Oostendorp, Robert A.J. )
• B03 - Toll-like receptor (TLR) independent immunogenicity of antigen expressing apoptotic (tumor)cells (Project Heads Schmitz, Frank ;  Wagner, Hermann )
• B4 - Selektive Modulation der Immunogenität von Tumorzellen mit Hilfe bifunktioneller Antikörperkonstrukte (Project Heads Kufer, Peter ;  Riethmüller, Gert )
• B05 - Synthetische und natürliche Integrin-Antagonisten zur therapeutischen Intervention beim Ovarialkarzinom (Project Heads Kessler, Horst ;  Reuning, Ute )
• B07 - MVA-based vectors for tumorantigen-specific stimulation in experimental immunotherapy (Project Head Drexler, Ingo )
• B8 - Nichtviraler rezeptorvermittelter Gentransfer zur Inhibierung von Tumorausbreitung und Metastasierung beim Mamma- und Ovarialkarzinom (Project Heads Plank, Christian ;  Schmitt, Manfred )
• B9 - Entwicklung neuer selektiver Inhibitoren für Integrine und ihr Einsatz in der Krebstherapie (Project Heads Kessler, Horst ;  Schmitt, Manfred )
• B10 - Generation of HER-specific T killer and T helper cells for adoptive transfer (Project Head Bernhard, Helga )
• B11 - Immunologische Erkennung des SV40 Tumorantigens und Regulation der tumorspezifischen Immunantwort in transgenen Mäusen (Project Head Förster, Irmgard )
• B12 - The role of steady-state MHC class I - CD8 T cell interaction in proliferative capacity and repertoire diversity (Project Head Brocker, Thomas )
• B13 - Analysis of immune-regulatory effects of NKG2D-ligands (Project Head Busch, Dirk )
• B14 - In vivo analysis of regulatory T cell (Treg) function during tumorigenesis: immunoregulation via specific manipulation of Tregs and optimized vaccination strategies (Project Head Sparwasser, Tim Dominik )
• Z01 - Zentrale Aufgaben des Sonderforschungsbereichs (Project Head Wagner, Hermann )
• Z03 - Cell Sorting Unit for the identification and purification of leukocytes, stem cells and tumor cells (Project Head Busch, Dirk )

• Applicant Institution: Technische Universität München (TUM)
• Participating University: Ludwig-Maximilians-Universität München
• Spokespersons: Professor Dr. Dirk Busch, since 1/2008; Professor Dr. Hermann Wagner, until 12/2007