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Project Details

Institution

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Philipps-Universität Marburg
Zentrum für Tumor- und Immunbiologie (ZTI)
Institut für molekulare Onkologie

Address Hans-Meerwein-Straße 3
35043 Marburg
Deutschland

GERiT This institution in GERiT

35043 Marburg

Projects

Clinical Research Units
- Completed projects
  - Exploring cancer therapies based on p53-reactivating drugs using shRNA barcode screening
    (Applicant Wanzel, Michael )
  - Role of p73 for drug resistance
    (Applicant Stiewe, Thorsten )
Research Grants
- Current projects
  - Mutant p53 mouse cancer models using somatic CRISPR base editing
    (Applicant Stiewe, Thorsten )
- Completed projects
  - Functional annotation of the TP53 mutome by CRISPR/Cas9-based saturating mutagenesis
    (Applicant Stiewe, Thorsten )
  - mTOR-mediated metabolic vulnerability of chemotherapy resistant cancer
    (Applicant Wanzel, Michael )
  - Role of DNA binding cooperativity for tumor suppression by p53
    (Applicant Stiewe, Thorsten )
  - Tumor addiction to late p53 inactivation
    (Applicant Timofeev, Oleg )
CRC/Transregios
- Completed projects
  - Gene expression profiling and functional genomics
    (Project Heads Ade, Carsten Patrick ; Wanzel, Michael )
  - Ras-dependent pathways in human cancer
    (Project Heads Gaubatz, Stefan ; Stiewe, Thorsten )
  - Role of p53 core domain interactions for target gene selection and tumor suppression
    (Project Head Stiewe, Thorsten )
  - Role of p73-directed chromatin alterations for neuroendocrine differentiation in small cell lung cancer
    (Project Head Stiewe, Thorsten )
  - Role of the Myc/Miz1 interaction in the co-operation of Ras and Myc
    (Project Heads Eilers, Martin ; Elsässer, Hans-Peter ; Wanzel, Michael )
Priority Programmes
- Completed projects
  - Epigenetics of the nuclear oncoprotein Ski in AML
    (Applicant Neubauer, Andreas )
Research Training Groups
- Current projects
  - GRK 2573: The inflammatory tumor secretome – from understanding to novel therapies
    (Spokesperson Pogge von Strandmann, Elke )

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