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Uniklinik Köln
Klinik für Innere Medizin I

Address 50924 Köln
Deutschland

GERiT This institution in GERiT

50924 Köln

Projects

Priority Programmes
- Current projects
  - Digital Transformation in Healthcare: From Digital Tools to Digital Actors (DigiAct)
    (Applicants Rosenkranz, Christoph ; Seeger-Nukpezah, Tamina ; Sunyaev, Ali )
- Completed projects
  - Bedeutung des "kidney injury molecule-1" für die Zell-Matrix-Wechselwirkung von renalen tubulären Epithelzellen nach ischämischer Nierenschädigung (Role of "kidney injury molecule-1" in cell-matrix interaction of renal tubular epithelial cells after ischemic injury to the kidney)
    (Applicant Schulze-Lohoff, Eckhard )
  - Zelleintritt und intrazelluläre Prozessierung von rAAV targeting Vektoren und ihrer Genome im lympho-hämatopoetischen System
    (Applicant Büning, Hildegard )
Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Clinical Trials
- Completed projects
  - Granulocyte Transfusion Therapy in Patients with Neutropenic Fever ("GRANITE")
    (Applicant Hübel, Kai )
Clinical Research Units
- Completed projects
  - Central diagnostics, genomics and biobanking
    (Applicants Büttner, Reinhard ; Herling, Carmen Diana ; Kreuzer, Karl-Anton )
  - Central diagnostics, genomics and biobanking
    (Applicants Herling, Carmen Diana ; Kreuzer, Karl-Anton ; Peifer, Martin )
  - Elucidation of the PI3K/AKT pathway in the transformation and progression of CLL
    (Applicants Pallasch, Christian Philipp ; Wunderlich, Frank Thomas )
  - Function of tyrosine kinases Lyn and Btk in high-risk CLL
    (Applicant Hallek, Michael )
  - Identification of resistance mechanisms for therapy of venetoclax-refractory high-risk CLLs
    (Applicant Frenzel, Lukas )
  - KFO 286: Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia
    (Spokesperson Hallek, Michael )
Research Units
- Current projects
  - FOR 5504: Physiological causes and consequences of genome instability
    (Spokesperson Schumacher, Björn )
  - Ubiquilins in DNA repair and neurodegeneration
    (Applicant Jachimowicz, Ron )
- Completed projects
  - Recombinant adeno-associated virus-mediated transgene delivery into porcine organs to allow immunological modifications of xenografts
    (Applicant Hallek, Michael )
Independent Junior Research Groups
- Current projects
  - Integrative Modelling of Plasticity, Evolution and Prognosis of Cancer
    (Applicant Al-Sawaf, Othman )
Collaborative Research Centres
- Current projects
  - A translational platform for longitudinal molecular studies of SCLC under therapy
    (Project Heads Höpker, Katja ; Lang, Ulrich ; Peifer, Martin ; Wesner, Stefan ; Wolf, Jürgen )
  - Central administration project
    (Project Head Hallek, Michael )
  - Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas
    (Project Heads Chapuy, Björn ; Eichhorst, Barbara )
  - Deciphering the role of BIRC3 in lymphomagenesis and resistance to therapy
    (Project Heads Pallasch, Christian Philipp ; Peltzer, Ph.D., Maria de las Nieves )
  - Harnessing defective DNA repair for the treatment of mantle cell lymphoma
    (Project Head Jachimowicz, Ron )
  - Integrated Research Training Group (“Cell-Death-RTG”)
    (Project Heads Misas Villamil, Johana ; Rybniker, Ph.D., Jan ; Schermer, Bernhard ; Zuccaro, Alga )
  - LYN kinase as a key regulator in the microenvironmental niche of B cell lymphoid tumors
    (Project Heads Hallek, Michael ; Nguyen, Ph.D., Phuong Hien )
  - Mechanisms and consequences of inflammasome mediated mitochondrial impairment in Mycobacterium tuberculosis infected myeloid cells
    (Project Head Rybniker, Ph.D., Jan )
  - Modeling the clonal evolution of high-risk CLL
    (Project Heads Fischer, Kirsten ; Peifer, Martin )
  - Multiparametric analysis of lymphoma cells and their microenvironment
    (Project Heads Büttner, Reinhard ; Frenzel, Lukas ; Oellerich, Thomas ; Peltzer, Ph.D., Maria de las Nieves ; Schweiger, Michal-Ruth )
  - New strategies to improve the efficiency and safety of CAR-T cells for the treatment of B cell lymphoma
    (Project Heads Chmielewski, Markus ; Ullrich, Roland Tillmann )
  - SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies
    (Spokesperson Hallek, Michael )
  - Understanding resistance towards venetoclax in lymphoma: physiology of genetic alterations in BTG1 and BCL2
    (Project Heads Frenzel, Lukas ; Garcia Sáez, Ana Jesús )
- Completed projects
  - Bestimmung der antigen-Spezifität der T-Zellantwort gegen eine genmodifizierte, polyvalente Vakzine bei der chronischen lymphatischen Leukämie (CLL)
    (Project Heads Hallek, Michael ; Hammerschmidt, Wolfgang ; Wendtner, Clemens-Martin )
  - Cell autonomous immune responses towards Adeno-associated virus (AAV) infection in the liver
    (Project Heads Büning, Hildegard ; Hallek, Michael )
  - Central administration
    (Project Head Hallek, Michael )
  - Detektion spezifischer genetischer Abberationen in primären Hodgkin-Reed Sternberg Zellen
    (Project Heads Diehl, Volker ; Jox, Andrea ; Wolf, Jürgen )
  - Harnessing molecular vulnerabilities to promote an antitumor immune microenvironment
    (Project Heads Herter-Sprie, Grit Sophie ; Reinhardt, Christian )
  - Lentiviral vector reprogrammed dendritic cells for immune reconstitution of T- and B-cells after allogeneic stem cell transplantation and protection against HCMV
    (Project Heads Messerle, Martin ; Stripecke, Renata )
  - Molecular imaging of interactions between the tumor environment and tumor growth
    (Project Heads Neumaier, Bernd ; Persigehl, Thorsten ; Ullrich, Roland Tillmann )
  - Molecular modulation of leukemia-associated macrophages in the microenvironment of chronic lymphocytic leukemia (CLL)
    (Project Heads Hallek, Michael ; Pallasch, Christian Philipp )
  - SFB 502: Molecular aspects of pathogenesis,diagnostics and therapy of morbus hodgkin and related diseases
    (Spokesperson Diehl, Volker )
  - SFB 832: Molecular Basis and Modulation of Cellular Interactions in the Tumour Microenvironment
    (Spokesperson Hallek, Michael )
  - Targeting von rekombinanten Adeno-assoziierten Virus-Vektoren
    (Project Head Hallek, Michael )
  - Validating therapeutic anti-angiogenic targets by a combined chemical genetics and imaging approach
    (Project Heads Thomas, Roman ; Ullrich, Roland Tillmann ; Wolf, Jürgen )
  - Vascular Targeting für das Hodgkin-Lymphom
    (Project Heads Engert, Andreas ; Gottstein, Claudia )
  - Zentrale Verwaltung und zentrale Laboratorien
    (Project Heads Diehl, Volker ; Tesch, Hans )
  - Zytokingentransfer in humane Non-Hodgkin Lymphom-Zellen
    (Project Head Wolf, Jürgen )
Research data and software
- Completed projects
  - Establishment of a dynamic expert and research network for virtual microscopy in hematology and oncology
    (Applicant Kreuzer, Karl-Anton )
WBP Fellowship
- Completed projects
  - Tracing cancer evolution and the metabolome: A cross-platform approach
    (Applicant Al-Sawaf, Othman )
Clusters of Excellence
- Completed projects
  - EXC 62: From Regenerative Biology to Reconstructive Therapy (REBIRTH)
    (Spokespersons Haverich, Axel ; Thum, Ph.D., Thomas )
  - EXC 229: Cellular Stress Responses in Aging-Associated Diseases
    (Spokesperson Brüning, Jens Claus )

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