Project Details
Projekt
SFB 621: Pathobiology of the Intestinal Mucosa
Subject Area
Medicine
Agriculture, Forestry and Veterinary Medicine
Biology
Agriculture, Forestry and Veterinary Medicine
Biology
Term
from 2002 to 2013
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5485201
The intestinal mucosa is the largest exposed surface of the macro-organism. It is the interface of the intestinal organ system and is a sensitive seismograph for external (infectious) and internal (immunological) disturbances to which it is exposed and which can seriously impair its physiological functions (uptake and excretion). Of these unresolved questions and problems, three major areas of research are initiated at the Hannover Medical School (Medizinische Hochschule Hannover), the School of Veterinary Medicine Hannover (Tierärztliche Hochschule) and German Research Centre for Biotechnology (Gesellschaft für Biotechnologische Forschung) in Braunschweig.
There is still much unknown about postnatal interference and adaptation of the normal bacterial flora to the innate immune system at the border layer of the intestinal mucosa and the ensuing, normally lifelong peaceful coexistence in which micro- and macro-organism show mutual respect. The collaborative research centre intends to focus on the E. coli strain Nissle 1917 as the central probiotic agent in various individual projects and animal models, to manipulate this strain genetically and to determine the complete genome sequence in order to explain its probiotic effects. Another interdisciplinary theme closely involved in the probiotic approach is the Gnotobiotic Central Project Z1. The use of gnotobiotic and subsequently intentionally infected knock-out mouse strains will be of great importance for the analysis of the influence of the intestinal flora on the development, perpetuation and therapy of IBD.
There is still much unknown about postnatal interference and adaptation of the normal bacterial flora to the innate immune system at the border layer of the intestinal mucosa and the ensuing, normally lifelong peaceful coexistence in which micro- and macro-organism show mutual respect. The collaborative research centre intends to focus on the E. coli strain Nissle 1917 as the central probiotic agent in various individual projects and animal models, to manipulate this strain genetically and to determine the complete genome sequence in order to explain its probiotic effects. Another interdisciplinary theme closely involved in the probiotic approach is the Gnotobiotic Central Project Z1. The use of gnotobiotic and subsequently intentionally infected knock-out mouse strains will be of great importance for the analysis of the influence of the intestinal flora on the development, perpetuation and therapy of IBD.
DFG Programme
Collaborative Research Centres
Completed projects
- A01 - The function of chemokines in the development of mucosal immunity, the induction of oral tolerance and the origin of colitis (Project Head Förster, Reinhold )
- A02 - Genetische Analyse von Interleukin-10-produzierenden und auf Interleukin-10 antwortenden Zellen im darmassoziierten lymphatischen Gewebe (Project Head Müller, Werner )
- A3 - Rolle der stress-aktivierten Proteinkinasen MK2 und MK5 bei entzündlichen Darmerkrankungen der Maus (Project Head Gaestel, Matthias )
- A04 - Entwicklung und Testung neuer Strategien zur spezifischen Modulation des mukosalen Immunsystems (Project Heads Bruder, Dunja ; Buer, Jan )
- A05 - Contribution of B cell subpopulations to gut-associated humoral immunity (Project Head Weiß, Siegfried )
- A7 - Funktionen des Dünndarmepithels bei Transport und Prozessierung von Antigenen (Project Head Lindner, Robert )
- A8 - Pathophysiologische Funktion von Mastzellen bei entzündlichen Darmerkrankungen (Project Head Bischoff, Stephan )
- A09 - Mukosale Immunität gegen Darm-Bakterien (Project Head Bumann, Dirk )
- A10 - The role of lymph node specific stromal cells in the regulation of the microenvironment and the immune response in the mesenteric lymph node (Project Head Bode, Ulrike )
- A11 - Structure, organogenesis and function of "solitary intestinal lymphoid tissue" (Project Head Pabst, Oliver )
- A12 - The role of antimicrobial peptides for the establishment and maintenance of the intestinal host-microbe homeostasis (Project Head Hornef, Mathias Walter )
- A13 - Foxp3+ Tregs in mucosal tolerance: sites of de novo induction and stability under inflammatory conditions (Project Head Hühn, Jochen )
- A14 - Investigation of the function, specificity and homing of yd T-cells and analysis of their role pathological processes in the intestinal mucosa (Project Head Prinz, Immo )
- A15 - The role of myeloid derived suppressor cells in the pathogenesis of inflammatory bowel disease (Project Head Greten, Tim F. )
- B02 - Molekulare Mechanismen der Reorganisation des Aktinzytoskeletts durch bakterielle Darmerreger (Project Heads Rottner, Klemens ; Wehland, Jürgen )
- B03 - Modulation der intestinalen Sekretion durch Escherichia coli Nissle 1917 (Project Heads Breves, Gerhard ; Schröder, Bernd )
- B4 - Determinanten und molekulare Mechanismen der Krankheitsmanifestationen der Helicobacter pylori Infektion (Project Heads Beil, Winfried ; Mähler, Michael ; Wagner, Siegfried )
- B05 - Proinflammatory efficts of Clostridium difficile toxins A and B (Project Head Gerhard, Ralf )
- B6 - Persistenzmechanismen von Mycobacterium paratuberculosis in Makrophagen und deren pathophysiologische Bedeutung im Darm (Project Heads Goethe, Ralph ; Valentin-Weigand, Peter )
- B07 - Importance of the surface protein S for the enteropathogenicity of transmissible gastroenteritis virus (TGEV) (Project Head Herrler, Georg )
- B08 - Molecular basis of Helicobacter hepaticus-induced pathogenesis in murine models of chronic inflammatory bowel disease (Project Head Suerbaum, Sebastian )
- B09 - Sequenzierung von E. coli Nissle 1917: Funktionelle Genomanalyse in vivo und in vitro und molekulare Analyse probiotischer Effekte (Project Head Gunzer, Florian )
- B10 - Characterization of the passage through the intestinal epithelium by Yersinia pseudotuberculosis during different stages of the infection (Project Head Dersch, Petra )
- C1 - Regulation epithelialer Wundheilungsmechanismen der Darmmukosa durch subepithiale Myofibroblasten (Project Head Göke, Michael )
- C03 - The molecular basis and genetic variability of mucosal UDP-glukuronosyltransferase (UGT) gene regulation in humans and the humanized UGTIA-SNP-C57BL/6 mouse model (Project Head Strassburg, Christian )
- C5 - Protektion von Epithelien des Magen-Darm-Trakts gegen gasförmige Noxen (Project Head Gros, Gerolf )
- C6 - CLCA-Chloridkanäle der intestinalen Mukosa von Maus und Mensch (Project Head Gruber, Ph.D., Achim Dieter )
- C07 - Genetic modifiers of cystic fibrosis in the intestine (Project Head Tümmler, Burkhard )
- C08 - Membrane topology of the small intestine in health and disease (Project Head Naim, Hassan Y. )
- C09 - Role of PDZ-adapter proteins of the NHERF family in the regulation of intestinal electrolyte transport and barrier function (Project Head Seidler, Ursula )
- C10 - Basolateral anion import pathways of the intestinal epithelium: Pathophysiological relevance in inflammatory bowel disease (Project Head Bachmann, Oliver )
- C11 - Genetic and immunological analysis of inflammatory bowel disease in children (Project Head Klein, Christoph )
- C12 - Role of serotonergic signaling in regulation of neuroimmune interactions within the gastrointestinal tract under physiological and pathological conditions (Project Head Ponimaskin, Evgeni )
- Z01 - Derivation, breeding, and maintenace of germfree mouse strains as well as gnotoxenic experiments (Project Heads Bleich, André ; Dorsch, Martina ; Hedrich, Hans-Jürgen )
- Z02 - Central Administration (Project Head Förster, Reinhold )
Applicant Institution
Medizinische Hochschule Hannover
Participating University
Stiftung Tierärztliche Hochschule Hannover
Participating Institution
Helmholtz-Zentrum für Infektionsforschung (HZI)
Spokesperson
Professor Dr. Reinhold Förster
