Die Funktion von EBA140 für die Invasion von Plasmodium falciparum in den Wirtserythrozyten und die Identifizierung des EBA140 Rezeptors

• Antragsteller: Professor Dr. Tim-Wolf Gilberger
• Fachliche Zuordnung: Parasitologie und Biologie der Erreger tropischer Infektionskrankheiten
• Förderung: Förderung von 2000 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5239138

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2004): Transfection of the human malaria parasite Plasmodium falciparum. Methods Mol. Biol. 270: 263-76
  Crabb, B.S., Rug, M., Gilberger, T.-W., Thompson, J.K., Triglia, T., Maier, A.G., Cowman, A.F.
  
• (2005): Re-defining the Golgi complex in P. falciparum using the novel Golgi marker PfGRASP. J. Cell Sci. 118: 5603-13
  Struck, N.S., de Souza Dias, S., Langer, C., Marti, M., Pearce, J.A., Cowman, A.F. and Gilberger T.-W.
  
• (2005): The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme. Mol. Biochem. Parasitol.142: 224-36
  Haider, N., Eschbach, M.-L., Dias, S., Gilberger, T.-W., Walter , R.-D. and Lüersen, K.
  
• (2006): A conserved molecular motor drives cell invasion and gliding motility across malaria lifecycle stages and other apicomplexan parasites. J. Biol. Chem. 281: 5197-208
  Baum, J., Richard, D., Healer, J., Rug, M., Krnajski, Z., Gilberger, T.-W., Green, J.L., Holder, A.A., Cowman, A.F.
  
• (2006): A conserved region in the EBL-proteins is implicated in microneme targeting of the malaria parasite Plasmodium falciparum. J. Biol. Chem. 281: 31995-2003
  Treeck, M., Struck, N.S., Haase, S., Langer, C., Herrmann, S., Healer, J., Cowman, A.F. and Gilberger, T.-W.
  
• (2006): Intermembrane proteloysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite. J. Cell. Biol. 174: 1023-33
  O´Donnell, R., Hackett, F., Howell, S.A., Treeck, M., Struck, N.S., Krnajski, Z., Withers-Martinez, C., Gilberger, T.-W. and Blackmann, M.J.
  
• (2006): The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine. Biol. Chem. 387: 1583-91
  Eschbach, M.L., Müller, I.B., Gilberger, T.W., Walter, R.D. and Wrenger, C.
  
• (2007): Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin O and equinatoxin II. Biochem J. 403: 167-175
  Jackson, K.E., Spielmann, T., Hanssen, E., Adisa, A., Separovic, F., Dixon, M.W., Trenholme K.R., Hawthorne, P.L., Gardiner, D.L., Gilberger, T. and Tilley, L.
  
• (2008): Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum. Infect. Immun. 76: 879-887
  Haase, S., Cabrera, A., Langer, C., Treeck, T., Struck, N., Herrmann, S., Jansen, P.W., Bruchhaus, I., Bachmann, A., Dias, S., Cowman, A.F., Stunnenberg, H.G., Spielmann, T. and Gilberger, T.W.
  
• (2008): Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism. J. Cell Sci. 121: 2123-29
  Struck, N.S., Herrmann, S., Langer, C., Krueger, A., Foth, B.J., Engelberg, K., Cabrera, A.L., Haase, S., Treeck, M., Marti, M., Cowman, A.F., Spielmann, T., and Gilberger, T.- W.
  
• (2008): Restricted ER export competence and Spatial dissection of the cis- and Trans-Golgi compartments in the malaria parasite Plasmodium falciparum. Mol. Micro. 67: 1320-30
  Struck, N.S., Herrmann, S., Schmuck-Barkmann, I., de Souza Diaz, S., Haase, S., Cabrera, A.L., Treeck, M., Bruns, C., Langer, C., Cowman, A.F., Marti, M., Tobias Spielmann, T. and Gilberger., T.-W.