Neural resources of mnemonic discrimination and their interaction with hidden pathology in older adults and SuperAgers (B02)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

In this study, we aim to investigate the meso-scale underpinnings of neural resources underlying pattern separation and pattern completion in older adults and 'SuperAgers' with quantified hidden pathology. To that end, we will utilise mobile app-based object- and scene-based mnemonic discrimination (pattern separation) training over 6 months. We will i) determine the upper limits of cognitive improvement and plasticity using behavioural, structural and functional measures, ii) quantify transfer and trade-offs at several levels (across different stimulus types within a modality, across modalities, across processes (pattern separation and completion), and iii) determine how hidden pathology affects plasticity and transfer.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Radoslaw Martin Cichy; Professor Dr. Emrah Düzel