Zelluläre Steuerung und Funktion der Isoenzyme von cGMP/cGMP-abhängigen Proteinkinasen

• Antragsteller: Professor Dr. Franz Hofmann
• Fachliche Zuordnung: Pharmakologie
• Förderung: Förderung von 2007 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 40833648

• Erstellungsjahr: 2011

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. The EMBO Journal, Vol. 26. 2007, Issue 21, pp. 4423-4432.
  Herrmann S. Stieber J, StöckIG, Hofmann F, Ludwig A
  (Siehe online unter https://dx.doi.org/10.1038/sj.emboj.7601868)
• IRAG mediates NO/cGMP-dependent inhibition of platelet Aggregation and thrombus formation. Blood, Vol. 109. 2007, Issue 2, pp. 552 - 559.
  Antl M, v. Brühl M-L, Eiglsperger C, Werner M, Konrad I, Köcher T, Wilm M, Hofmann F, Massberg S, Schlossmann J
  
• Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circulation Research, Vol. 101. 2007, Issue 11, pp. 1096-1103.
  Weber S, Bernhard D, Lukowski R, Weinmeister P, Wörner R, Wegener JW, Feil S, Schlossmann J, Hofmann F, Feil R
  (Siehe online unter https://dx.doi.org/10.1161/CIRCRESAHA.107.154351)
• The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. The Journal of Cell Biology, vol. 179. 2007, Issue 2, pp. 331-340.
  Schmidt H, Stonkute A, Jüttner R, Schäffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG.
  (Siehe online unter https://dx.doi.org/10.1083/jcb.200707176)
• Anemia and splenomegaly in cGKI-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 18, pp. 6771 - 6776.
  Poller M, Feil S, Ghoreschi K, Koka S, Gerting A, Thunemann M, Hofmann F, Schüler B, Vogel J, Pichler B, Kasinathan RS, Nicolay JP, Huber SM, Lang F, Fell R.
  (Siehe online unter https://dx.doi.org/10.1073/pnas.0708940105)
• cGMP-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cell. Molecular Biology of the Cell, vol. 19. 2008, no. 10, pp. 4434-4441.
  Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L, Hofmann F, Feil R
  (Siehe online unter https://dx.doi.org/10.1091/mbc.E08-04-0370)
• Cysteine-rich protein 2, a novel downstream effector of cGMP / cGMPdependent protein kinase I mediated persistent inflammatory pain. The Journal of Neuroscience, Vol. 28. 2008, Issue 6, pp. 1320-1330.
  Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher, HD, Hofmann F, Tegeter 1, Ruth P, Geisslinger, G
  (Siehe online unter https://dx.doi.org/10.1523/JNEUROSCI.5037-07.2008)
• Phosphorylation of GSK-3 ß by cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth. Journal of Clinical Investigation, Vol. 118. 2008, Issue 7, pp. 2506-2515.
  Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U, Kawaguchi H
  (Siehe online unter https://dx.doi.org/10.1172/JCI35243)
• Role of smooth muscle cGMP/cGKl signaling in murine vascular restenosis. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 28. 2008, Issue 8, pp. 1244-1250.
  Lukowski R, Weinmeister P, Bernhard D, Feil S, Gotthardt M, Herz J, Massberg S, Zemecke A, Weber C, Hofmann F, Feil R.
  (Siehe online unter https://dx.doi.org/10.1161/ATVBAHA.108.166405)
• Signaling through cGMPdependent protein kinase I in the amygdala is critical for auditorycued fear memory and long-term potentiation. Journal of Neuroscience, Vol. 28. 2008, Issue 52, pp. 14202-14212.
  Paul C. Schöberl F, Weinmeister P, Micale V, Wotjak CT, Hofmann F, Kleppisch T
  (Siehe online unter https://dx.doi.org/10.1523/JNEUROSCI.2216-08.2008)
• Tamoxifen-inducible gene deletion in the Cardiac conduction system. Journal of Molecular and Cellular Cardiology. Vol. 45. 2008, Issue 1, pp. 62–69.
  HoesI E, Stieber J, Hen-mann S, FeilS, Tybl E, Hofmann F, Feil R, Ludwig A.
  (Siehe online unter https://dx.doi.org/10.1016/j.yjmcc.2008.04.008)
• cGMP kinase and RhoA Ser188 phosphorylation integrate pro- and anti-fibrotic signals in blood vessels. Molecular and Cellular Biology, vol. 29. 2009, no. 22, pp. 6018-6032.
  Sawada N, Itoh H, Miyashita K, Tsujimoto H, Sone M, Yamahara K, Arany ZP, Hofmann F, Nakao K.
  (Siehe online unter https://dx.doi.org/10.1128/MCB.00225-09)
• cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal neovascularization. PLOS One 4: e4879.
  Aicher A, Heeschen C, Fell S, Hofmann F, Mendelsohn ME, Feil R, Dimmeler, S
  (Siehe online unter https://dx.doi.org/10.1371/journal.pone.0004879)
• cGMP-dependent Protein Kinase II and Aldosterone Secretion. FEBS Journal, Vol. 276. 2009, Issue 4, pp. 1007–1013.
  Spießberger B, Bernhard D, Herrmann S, Feil S, Werner C, Luppa PB, Hofmann F.
  (Siehe online unter https://dx.doi.org/10.1111/j.1742-4658.2008.06839.x)
• Combined reporter gene PET and iron oxide MR imaging for Monitoring Survival and Localization of Transplanted Cells in the Rat Heart. Journal of Nuclear Medicine, Vol. 50. 2009, no. 7, pp. 1088-1094.
  Higuchi T, Anton M, Dumler K, Seidl S, Pelisek J, Saraste A, Welling A, Hofmann F, Oostendorp RAJ, Gänsbacher B, Nekolla SG, Bengel FM, BotnarRM, Schwaiger M.
  (Siehe online unter https://dx.doi.org/10.2967/jnumed.108.060665)
• Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory Neurons. Journal of Neuroscience, Vol. 29. 2009, Issue 5, pp. 1350-1360.
  Zhao Z. Wang Z. Gu Y, Fell R, Hofmann F, Ma L.
  (Siehe online unter https://dx.doi.org/10.1523/JNEUROSCI.3770-08.2009)
• Cardiac hypertrophy is not amplified by deletion of cGMPdependent protein kinase type I in cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America, Vol. 107. 2010, Issue 12, pp. 5646-5651.
  Lukowski R, Rybalkin SD, Loga F. Leiss V, Beavo JA, Hofmann F.
  (Siehe online unter https://dx.doi.org/10.1073/pnas.1001360107)
• cGMP-dependent protein kinase type I promotes CREB/CRE-mediated gene expression In neurons ofthe lateral amygdala. Neuroscience Letters, Vol. 473. 2010, Issue 2, pp. 82–86.
  Paul C, Stratil C, Hofmann F, Kleppisch T.
  (Siehe online unter https://dx.doi.org/10.1016/j.neulet.2010.02.020)
• IRAG determines NO- and ANP-mediated smooth muscle relaxation. Cardiovascular Research, Vol. 86. 2010, pp. 496–505.
  Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, Jochim A, Spiessberger B, Hocherl K, Fell R, Fell S, Lukowski R, Wegener JW, Hofmann F, Schlossmann J
  (Siehe online unter https://dx.doi.org/10.1093/cvr/cvq008)