Platelet-dependent injury and safeguard mechanisms in acute ischaemic stroke (B02)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 374031971

We have shown that platelets and immune cells jointly drive penumbral tissue loss and ischaemia/reperfusion injury under and after middle cerebral artery occlusion in mice, and confirmed the concept of thrombo-inflammation in the human system using local pial blood samples obtained directly from the cerebral collateral circulation. As next steps we will characterise the contribution of platelet-derived DAMPs and platelet-dependent neutrophil effects on stroke development and collateral blood flow in a tandem experimental/human approach.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 240: Platelets – Molecular, cellular and systemic functions in health and disease
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Mirko Pham; Professor Dr. Michael Schuhmann, since 7/2022; Professor Dr. Guido Stoll