Casein kinase dependent signalling in platelet activation and thrombopoiesis (A02)

• Subject Area: Cell Biology ; Hematology, Oncology ; Cardiology, Angiology
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 374031971

In this project, we aim to investigate the role of Casein kinase (CK) 1 and 2 dependent signalling pathways involved in megakaryocyte (MK) development, including regulation of MK cytoskeleton and proplatelet formation, which are all elemental for thrombopoiesis or thrombocytopenic disorders. Additionally, vesicular trafficking, tubulin-dependent processes in platelet adhesion, activation and intracellular Ca2+ increase will be investigated, which are all critically involved in arterial thrombus formation and thrombotic disorders, such as myocardial infarction or ischaemic stroke.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 240: Platelets – Molecular, cellular and systemic functions in health and disease
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Professor Dr. Oliver Borst