Evaluierung von Cholin- und Acetat-Derivaten zur Anwendung in der nicht-invasiven Bildgebung beim Prostata-Karzinom
Zusammenfassung der Projektergebnisse
PET is used to detect and stage cancer because of its unique strength in providing noninvasive assessment of metabolic and physiological rates through tracer techniques. We could show, that in addition to that MR also offers inimitable chances in cancer diagnosis, due to its high soft tissue contrast as well as its ability to perform multiple imaging techniques such as magnetic resonance spectroscopy, diffusion weighted and functional imaging. Furthermore, androgen-ablation-therapy has been an important step in the treatment of prostate cancer for the last decades. Now, we showed that this highly responsive therapy can be monitored with 11C-choline PET (and its derivates). Additionally, we evaluated a new animal model that turned out being very close to the clinic and very useful for investigation of the progression of prostate cancer as well as examination of treatment efficacy. Furthermore, we could demonstrate a correlation between the two different imaging modalities (tracer uptake / DWI) as well as molecular methods like immunohistochemistry. Thus, it can be concluded that the PAC120 tumor bearing nude rat is a useful in vivo model to study new PET tracers for diagnostic and therapy efficacy monitoring in human hormonedependent prostate cancer. Most important, we could show that choline tracers behave similar to what is found in patients in the rat prostate tumor model but not in the mouse model. Thus, there is huge species dependence!
Projektbezogene Publikationen (Auswahl)
-
(2010). PET Biomarker Studies in the Human hormonedependent Prostate Cancer Rat-Xenograft-Tumor-Model PAC120 by Mimicking an Androgen Ablation Therapy through Surgical Castration. Nuklearmedizin 2: A19
Kukuk D, Reischl G, Wehrl H, Schmid A, Raguin O, Honndorf VS, Wiehr S, Duchamp O, Mannheim J, Pichler BJ
-
(2010). PET Study with [11C]Choline and its Derivates in a Human hormone-dependent Prostate Cancer Model xenografted in the Nude rat. WMIC, Kyoto, Japan
Kukuk D, Raguin O, Wehrl H, Calaminus C, Schmid A, Honndorf VS, Wiehr S, Duchamp O, Ehrlichmann W, Mannheim J, Reischl G, Pichler BJ
-
(2011). Assessment of PET Tracer Uptake in Hormone-Independent and Hormone-Dependent Xenograft Prostate Cancer Mouse Models. J. Nucl. Med. 52: 1654-1663
Kukuk D, Reischl G, Raguin O, Wiehr S, Judenhofer MS, Calaminus C, Honndorf VS, Quintanilla-Martinez L, Schönberger T, Duchamp O, Machulla HJ, Pichler BJ
-
(2011). PET tracer evaluation in the PAC120 human hormone-dependent prostate cancer xenograft rat model. J. Nucl. Med. 52: S310
Kukuk D, Wehrl H, Raguin O, Schmid A, Mannheim J, Reischl G, Pichler BJ
-
Untersuchungen zur Anwendbarkeit radiomarkierter Cholin-PET-Tracer zur Darstellung des Prostatakarzinoms im Tiermodell. Dissertation (Dr.rer.nat.). Universität Tübingen 2012
Kukuk D
