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Projekt Druckansicht

Interaktion von thrombozytären Enzündungsmediatoren und deren Rezeptoren CXCR4 und CXCR7 für die Thrombozytenfunktion und Inflammation

Fachliche Zuordnung Kardiologie, Angiologie
Förderung Förderung von 2011 bis 2019
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 190538538
 

Zusammenfassung der Projektergebnisse

We explored the role of inflammatory mediators and their cognate receptors CXCR4-CXCR7 in regulating thrombotic and thromboinflammatory attributes of platelets. To briefly summarize our investigation and research output we highlight the following: We established CXCR4 and CXCR7 on platelets as functional receptors for several chemokines like CXCL11, CXCL12, CXCL14 and the chemokine like cytokine macrophage migration inhibitory factor (MIF). CXCR4 and CXCR7 are preferentially engaged by these ligands and differentially regulate platelet survival and pro/anti-thrombotic response and their thromboinflammatory interaction with inflammatory cells like monocytes. - We characterized the impact and relative significance of the genetic deletion of CXCR4 and CXCR7 from megakaryocyte-platelet lineage in governing platelet responsiveness under basal conditions and following myocardial infarction (MI) and cerebral stroke. - We identified platelets as a novel source of the chemokine CXCL14 and Gremlin-1, a functional antagonist of MIF, both of which can regulate thrombotic and thromboinflammatory platelet functions. - We demonstrated the clinical significance of platelet CXCR4-CXCR7 in the context of coronary artery disease (CAD), established the prognostic significance of these receptors on platelets along with other platelet based biomarkers like CXCL14 and circulatory biomarkers like MIF and Gremlin-1.

Projektbezogene Publikationen (Auswahl)

 
 

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