Quantitative studies of metabolism (F-18-deoxyglucose) and bone metabolism (F-18-fluoride) with dynamic positron emission tomography-computed tomography (dPET-CT) ((14) B09)

• Subject Area: Orthopaedics, Traumatology, Reconstructive Surgery
• Term: from 2010 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 107540325

Patient studies: PET-CT studies will be performed in patients with multiple myeloma (MM) after application of F-18-Fluorodeoxyglucose (FDG) and F-18-Fluorodeoxythymidin (FLT) (n=60 patients) or Ga-68-Pentixafor (n=40 patients) prior and after therapy. All tracers will be compared with the clinical based MRD (minimal residual disease). PET-CT and PET-MRI studies will be performed (n=60 pa-tients) and each component will be compared with each other as well as with diagnostic MRI (B8) and gene expression data (B1). Animal studies: Osteoporotic rats with a femur defect will be studied with PET-CT using FDG and NaF in cooperation with T1 and T2. Different biomaterials will be assessed by FDG and NaF with respect to new bone formation and defect healing. The imaging data will be compared to histologic and gene expression data (B12).

• DFG Programme: CRC/Transregios
• Subproject of: TRR 79: Materials for Tissue Regeneration within Systemically Altered Bone
• Applicant Institution: Justus-Liebig-Universität Gießen
• Co-Applicant Institution: Deutsches Krebsforschungszentrum (DKFZ); Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professorin Dr. Antonia Dimitrakopoulou-Strauss; Professor Dr. Hartmut Goldschmidt; Professor Dr. Ludwig Georg Strauss, until 5/2013 (†)