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Professorin Dr. Brunhilde Wirth

Address Uniklinik Köln
Institut für Humangenetik
Kerpener Straße 34
50931 Köln

Projects

As Applicant
- Current projects
  - Unravelling of pathomechanisms for plastin 3 associated bone and cartilage diseases (Research Units)
- Completed projects
  - Aufklärung der Funktion des TFNR-Proteins und Beteiligung an der Gehirnentwicklung (Research Grants)
  - Molekulare und funktionelle Analyse von modifizierenden Genen bei spinaler Muskelatrophie (Research Grants)
  - Analysis of the influence of histone deacetylase inhibitors on the SMN2 histone code and the pathogenesis of spinal muscular atrophy (Research Grants)
  - Plastin 3: Unravelling a novel pathomechanism for osteoporosis (Research Grants)
  - Spinal muscular atrophy: Analysis of pathomechanistic impact of protective genetic modifiers in mouse models (Research Grants)
  - The power of protective modifier NCALD to develop an efficient combinatorial therapy for spinal muscular atrophy (Research Grants)
  - Gene identification and functional analyses of genetically unsolved patients with neuromuscular disorders (Research Grants)
  - The role of miRNA biogenesis and decay in spinal muscular atrophy (Research Grants)
As Participating Researcher
- Completed projects
  - GRK 246: Pathogenesis of Diseases of the Central Nervous System (Research Training Groups)
  - GRK 1960: Neural Circuit Analysis on the Cellular and Subcellular Level (Research Training Groups)
As Project Head
- Current projects
  - Understanding plastin 3 and its interactors in motor neuron function and plasticity in health and disease (Collaborative Research Centres)
- Completed projects
  - Analyse der molekularen Ursachen der spinalen Muskelatrophie als Grundlage einer Therapie (Collaborative Research Centres)

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