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Institution
Universitätsklinikum Hamburg-Eppendorf
Zentrum für experimentelle Medizin
Institut für Biochemie und Molekulare Zellbiologie
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Research Grants
Current projects
Impact of calcium and adenine nucleotide signaling on education and functionality of NK cells
(Applicants
Altfeld, Marcus
;
Diercks, Bjoern-Philipp
)
Influence of cold-induced energy expenditure on bone remodeling
(Applicants
Heeren, Jörg
;
Schinke, Ph.D., Thorsten
)
Completed projects
Apolipoprotein A5: Funktion im Fettstoffwechsel und Bedeutung bei der Entstehung der Arteriosklerose
(Applicant
Merkel, Martin
)
Bedeutung der Apolipoprotein E-Isoformen im Chylomikronen Stoffwechsel
(Applicant
Heeren, Jörg
)
Intrazelluläre Konsequenzen der Chylomikronen Remnant Aufnahme
(Applicant
Beisiegel, Ulrike
)
Mechanismen der Regulation der freien intrazellulären Ca2+-Konzentration durch Ca2+-Freisetzung und Ca2+-Einstrom in aktivierten T-Lymphozyten
(Applicant
Guse, Andreas H.
)
Molekulare Mechanismen der Aktivierung humaner Monozyten durch Lipopolysaccharid
(Applicant
Hauschildt, Sunna
)
Molekulare Wirkorte des Calcium-mobilisierenden Second Messengers cyclic ADP-ribose in T-Lymphocyten und Fibroblasten
(Applicant
Guse, Andreas H.
)
Nicotinic acid adenine dinucleotide phosphate (NAADP): A calcium mobilizing second-messenger in T-lymphocytes
(Applicant
Guse, Andreas H.
)
Role of the purine nucleotide messengers cyclic ADP-ribose and ADP-ribose in T-lymphocyte biology
(Applicant
Guse, Andreas H.
)
Ryanodine receptors and NAADP in T cell biology
(Applicants
Flügel, Alexander
;
Guse, Andreas H.
)
The contribution of brown and BRITE adipocytes to adaptive thermogenesis and body weight regulation
(Applicant
Klingenspor, Martin
)
The role of ChREBP-dependent de novo lipogenesis in metabolic and thermogenic activities of brown and white adipose tissue
(Applicant
Scheja, Ludger
)
The role of the nucleotide-gated cation channels P2X7 and TRPM2 for TCR signalling
(Applicants
Guse, Andreas H.
;
Haag, Friedrich
)
Research Units
Current projects
FOR 5705: NeuroFlame – Defence and demise of inflamed neurons
(Spokesperson
Friese, Manuel A.
)
Neuronal NAADP signalling during neuroinflammation
(Applicants
Freichel, Marc
;
Guse, Andreas H.
)
Completed projects
Analyse von DNA-Polymorphismen ausgewählter Kandidatengene bei der nicht-monogenen Form der Alzheimer-Demenz. Zentrale Datenbank und Gewebeproben-Ressourcen-Zentrum
(Applicant
Gal, Andreas
)
Apolipoprotein E, Lipide und Lipidperoxidation in der Pathogenese der Alzheimer Demenz
(Applicant
Beisiegel, Ulrike
)
FOR 267: Molekulare Pathomechanismen der Alzheimer-Demenz
(Spokesperson
Beisiegel, Ulrike
)
Molekulare Pathomechanismen der Alzheimer-Demenz
(Applicant
Nitsch, Roger
)
Role of Ca2+ mobilizing second messenger NAADP in local and global Ca2+ signalling in mouse cardiac myocytes
(Applicant
Guse, Andreas H.
)
Heisenberg Professorships
Completed projects
The role of immuno-metabolic networks for obesity associated diseases
(Applicant
Heeren, Jörg
)
Clinical Research Units
Current projects
KFO 5029: Precision Medicine for Early-Onset Low Bone Mineral Density Disorders
(Spokesperson
Amling, Michael
)
Molecular analysis of the bidirectional crosstalk between bone and lipid metabolism
(Applicant
Heeren, Jörg
)
Completed projects
Gut bacteria-derived Metabolites and their Impact on the Pathogenesis of Primary Sclerosing Cholangitis
(Applicant
Heeren, Jörg
)
KFO 306: Primär Sklerosierende Cholangitis
(Spokesperson
Lohse, Ansgar W.
)
Heisenberg Grants
Completed projects
Role of immunometabolic networks for obesity-associated diseases
(Applicant
Heeren, Jörg
)
Collaborative Research Centres
Current projects
Adenine nucleotide control of dendritic cell migration
(Project Head
Sáez, Pablo
)
Dynamic architecture of Ca2+ microdomains in T cells: disentangling contribution of adenine nucleotides, Ca2+ release and Ca2+ entry
(Project Heads
Diercks, Bjoern-Philipp
;
Werner, René
;
Wolf, Insa
)
Impact of purinergic signaling on epithelial cell-adipocyte crosstalk in intestinal inflammation and fibrosis in Crohn’s Disease
(Project Heads
Bunders, Ph.D., Madeleine
;
Worthmann, Anna
)
Management and coordination of the CRC
(Project Head
Guse, Andreas H.
)
Purinergic receptors in adipose tissue inflammation and adaptive thermogenesis
(Project Heads
Heeren, Jörg
;
Koch-Nolte, Friedrich
)
Ryanodine receptors and NAADP in T cell biology
(Project Heads
Flügel, Alexander
;
Guse, Andreas H.
)
SFB 1328: Adenine Nucleotides in Immunity and Inflammation
(Spokesperson
Guse, Andreas H.
)
Completed projects
Harnessing hepatic tolerance mechanisms for antigen-specific treatment of autoimmune and allergic diseases
(Project Heads
Carambia, Antonella
;
Heeren, Jörg
;
Herkel, Johannes
)
Rolle von Lipoproteinen und deren Rezeptoren in der Entwicklung des zentralen Nervensystems
(Project Head
Beisiegel, Ulrike
)
The role of anti-inflammatory bile acids for the development and progression of non-alcoholic steatohepatitis (NASH)
(Project Head
Heeren, Jörg
)
Priority Programmes
Completed projects
Interactions of hydrophobic and hydrophilic semiconductor quantum dots with cell model systems for liver and adipose tissue (NANOFATE)
(Applicants
Eychmüller, Alexander
;
Heeren, Jörg
;
Nielsen, Peter
)
Science Communication, Research Data, eResearch
Completed projects
Open Access Publishing 2016 - 2017 / University of Göttingen
(Applicant
Beisiegel, Ulrike
)
Major Research Instrumentation
Completed projects
Konfokales Laserscanning-Mikroskop
Spinning Disk Microscope
Stoffwechsel-Käfigsystem
CRC/Transregios
Current projects
Intestinal metabolites and their impact on thermogenic responses by brown and white adipose tissues
(Project Heads
Heeren, Jörg
;
Schwinge, Dorothee
)
Module Integrated Research Training Group (iRTG)
(Project Heads
Fenske, Wiebke Kristin
;
Klingenspor, Martin
;
Worthmann, Anna
)
Regulation of energy metabolism in brown fat through lipid uptake and lipid processing in adipose tissue macrophages
(Project Heads
Bosurgi, Ph.D., Lidia
;
Worthmann, Anna
)
Relevance of endothelial lipoprotein processing for thermogenic adipose tissue plasticity and function
(Project Head
Heeren, Jörg
)
The role of ChREBP-dependent de novo lipogenesis in metabolic and thermogenic activities of brown and white adipose tissue
(Project Head
Scheja, Ludger
)
Research Training Groups
Completed projects
GRK 336: Molecular Endocrinology - Molecular Metabolism
(Spokesperson
Seitz, Hans-Joachim
)
GRK 1459: Sorting and Interactions Between Proteins of Subcellular Compartments
(Spokesperson
Braulke, Thomas
)
Additional Information
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