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Institution
Universitätsklinikum Schleswig-Holstein
Campus Lübeck
Klinik für Dermatologie, Allergologie und Venerologie (Hautklinik)
Address
Ratzeburger Allee 160
23562 Lübeck
Deutschland
GERiT
This institution in GERiT
23562 Lübeck
Projects
Research Grants
Current projects
Clinician Scientist School Lübeck: Connecting Brain, Metabolism, and Inflammation (BMI) – Mechanisms and Disease Expression
(Applicant
Sadik, Christian David
)
Pathogenicity of autoantibodies in anti-p200 pemphigoid - impact of anti-laminin β4 IgG
(Applicant
Goletz, Ph.D., Stephanie
)
Completed projects
Autoimmunität gegen Typ VII Kollagen: Rolle des Komplementsystems für die Induktions- und Effektor-Phase der Autoimmunantwort
(Applicant
Zillikens, Detlef
)
Contribution of T cells to immune complex-induced tissue damage
(Applicant
Ludwig, Ralf Joachim
)
Dual contribution of the spleen tyrosine kinase (SYK) to epidermolysis bullosa acquisita pathogenesis
(Applicants
Ludwig, Ralf Joachim
;
Samavedam, Ph.D., Unni Krishna
)
Influence of collagen modifying enzymes on cross-linking
(Applicant
Brinckmann, Jürgen
)
Metabolic impact of a polymorphism in the mitochondrial gene mt-Cytb on the pathogenesis of psoriasis
(Applicants
Ibrahim, Saleh M.
;
Schilf, Paul
)
Pathogenesis of blister formation in bullous pemphigoid: studies on signal transduction through the 180kDa auto-antigen (BP180/type XVII collagen)
(Applicant
Zillikens, Detlef
)
Pathogenicity of IgA-type autoantibodies in pemphigoid disease
(Applicants
Ludwig, Ralf Joachim
;
Nimmerjahn, Falk
;
Recke, Andreas
)
Plasmazelldepletion über Aktivierung der unfolded protein response: Rolle von Hitzeschockprotein 90-Inhibitoren im Mausmodell der Autoantikörper-vermittelten Epidermolysis bullosa acquisita
(Applicant
Kasperkiewicz, Michael
)
Regulation der Entzündung bei der durch Antikörper gegen die dermo-epidermale Junktionszone induzierten Blasenbildung
(Applicant
Zillikens, Detlef
)
The role of leukotriene B4 and its receptor BLT1 in the pathogenesis of the prototypical organ-specific autoimmune disease epidermolysis bullosa acquisita
(Applicant
Sadik, Christian David
)
Clinical Research Units
Completed projects
Administrative unit
(Applicant
Sadik, Christian David
)
Biostatistics and Systems Medicine Core Unit (Z2-Project)
(Applicants
Busch, Hauke
;
Erdmann, Jeanette
;
Koenig, Inke Regina
;
Sadik, Christian David
)
Central Clinical Infrastructure (Z1-Project)
(Applicants
van Beek, Nina
;
Sadik, Christian David
;
Schmidt, Enno
;
Zillikens, Detlef
)
HCA2 activation in Pemphigoid Diseases - therapeutic effect and mode of action
(Applicants
Schwaninger, Markus
;
Zillikens, Detlef
)
KFO 303: Pemphigoid Diseases - Molecular Pathways and their Therapeutic Potential
(Spokesperson
Zillikens, Detlef
)
Lipid Mediator-orchestrated molecular Mechanisms resolving Skin Inflammation in Pemphigoid Diseases
(Applicant
Sadik, Christian David
)
The Role of Monocyte-derived Cells and the molecular Mechanisms of their Recruitment in the Pathogenesis of Pemphigoid Diseases
(Applicants
König, Peter
;
Sadik, Christian David
)
Collaborative Research Centres
Current projects
Central Tasks of the Collaborative Research Center
(Project Head
Sadik, Christian David
)
Clinical Research Support
(Project Heads
Becker, Mareike
;
Heine, Guido
;
Holtsche, Maike Marleen
;
Sadik, Christian David
)
G protein-coupled receptors orchestrating granulocytes in pemphigoid diseases
(Project Heads
Sadik, Christian David
;
Wettschureck, Nina
)
Pathophysiology of granulocyte metabolism and its potential as therapeutic target in pemphigoid diseases
(Project Heads
Sadik, Christian David
;
Schilf, Paul
)
Preclinical model systems of pemphigoid diseases
(Project Heads
Ludwig, Ralf Joachim
;
Murthy, Sripriya
)
Role of the complement receptors 1 and 2 as drivers of autoantibody development and their potential as drug targets in pemphigoid diseases
(Project Heads
Hammers, Matthias Christoph
;
Verschoor, Ph.D., Admar
)
SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
(Spokespersons
Ludwig, Ralf Joachim
;
Sadik, Christian David
;
Zillikens, Detlef
)
Stromal regulation of inflammation in pemphigoid diseases
(Project Head
Hoffmann, Markus
)
Completed projects
Amplification of NET formation and neutrophil aggregation for the resolution of inflammation
(Project Heads
Herrmann, Martin
;
Hoffmann, Markus
)
Quervernetzungsmuster im Kollagen sklerosierender Hauterkrankungen
(Project Head
Brinckmann, Jürgen
)
Research Fellowships
Completed projects
Changing the anti-tumor immune response through differentially glycosylated tumor-specific IgG
(Applicant
Prüßmann, Jasper
)
Interleukin 9 (IL-9) in anticancer immune responses against melanoma in mice and human
(Applicant
Prüßmann, Wiebke
)
Leukotrien B4 als Regulator chemotaktisch-aktiver Substanzen in der Pathogenese chronischer Arthritiden
(Applicant
Sadik, Christian David
)
Longitudinal cloning and genetic characterization of human pemphigus autoantibodies in active disease, remission, and relapse
(Applicant
Hammers, Matthias Christoph
)
Priority Programmes
Completed projects
The role of the oxidative burst in bone remodeling during chronic inflammation
(Applicants
Herrmann, Martin
;
Hoffmann, Markus
)
Research Units
Current projects
FOR 2886: PANDORA - Pathways triggering AutoimmuNity and Defining Onset of early Rheumatoid Arthritis
(Spokesperson
Krönke, Gerhard
)
Completed projects
Metabolic and dietary control of mesenchymal tissue priming and persistence of arthritis
(Applicants
Hoffmann, Markus
;
Mougiakakos, Dimitrios
)
Research Training Groups
Current projects
GRK 2633: Defining and Targeting Autoimmune Pre-Disease
(Spokesperson
Ludwig, Ralf Joachim
)
Completed projects
GRK 1727: Modulation of Autoimmunity
(Spokesperson
Zillikens, Detlef
)
Clusters of Excellence
Completed projects
EXC 306: Inflammation at Interfaces
(Spokesperson
Schreiber, Stefan
)
Graduate Schools
Completed projects
GSC 235: Graduate School for Computing in Medicine and Life Sciences
(Spokesperson
Schweikard, Achim
)
Clusters of Excellence (ExStra)
Current projects
EXC 2167: Precision Medicine in Chronic Inflammation (PMI)
(Spokespersons
Niemann, Stefan
;
Riemekasten, Gabriela
;
Schreiber, Stefan
)
Additional Information
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