GRK 1216:  Intra- and Intercellular Transport and Communication

• Subject Area: Basic Research in Biology and Medicine
• Term: from 2006 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 948344

• Final Report Year: 2015

Final Report Abstract

Pro- und eukaryote Zellen zeichnen sich durch eine regulierte, strukturelle, zeitliche und räumliche Organisation aus. Für deren Aufrechterhaltung sind dynamische Verteilungsmechanismen notwendig, welche dafür sorgen, die beteiligten Moleküle zur richtigen Zeit am richtigen zellulären Ort bereitzustellen. Das Graduiertenkolleg 1216 befasste sich mit einem Teilaspekt dieses Themas, dem intra- und interzelluären Transport und der Kommunikation. Hierbei wurden, gegliedert in drei Unterbereiche, (i) die molekulare Basis von Zell-Zell-Interaktionen, (ii) die Zellpolarität sowie (iii) die Etablierung und Aufrechterhaltung zellulärer Kompartimentierung untersucht. Neben wichtigen eukaryoten Modell-Organismen wurden auch Bakterien als Untersuchungsobjekte herangezogen, um dem in den letzten Jahren geradezu explodierenden Wissenszuwachs auf dem Feld der Zellbiologie der Prokaryoten Rechnung zu tragen. In der neunjährigen Förderphase des Graduiertenkollegs 1216 wurden die wissenschaftlichen Themen erfolgreich bearbeitet und weiterentwickelt. Dies zeigen u.a. die erfolgreich abgeschlossenen Dissertationen sowie die Publikationen, an denen die Kollegiaten beteiligt sind. So konnten in sehr guten bis hin zu high impact Journalen wichtige Teilbereiche veröffentlicht werden (z.B. Nature, Science, PNAS). Parallel zu den experimentellen Arbeiten wurden die Kollegiaten in ein Ausbildungsprogramm integriert, das entscheidend zur ihrer Karriereentwicklung beitrug. Neben der Teilnahme an Workshops zu wissenschaftlichen Themen und zu soft skills, wurden in regelmäßigen Vortragsveranstaltungen die Präsentationstechniken der Kollegiaten verbessert. Unter dem Dach des GRK 1216 konnten die Kollegiaten von weiteren Veranstaltungen profitieren. So ermöglichte das GRK 1216 die Teilnahme an und die Organisation von Kongressen sowie Besuche von externen Arbeitsgruppen, bei denen die Kollegiaten über den Marburger Tellerrand blicken konnten. Das im GRK1216 entwickelte, strukturierte Ausbildungsprogram setzte entscheidende Akzente, die nun auch in anderen Programmen der Philipps-Universität weiterentwickelt werden. Schließlich bestand eine überaus fruchtbare und intensive Kooperation und Kommunikation mit dem SFB 593.

Publications

• (2006) Dual function of the germinal centre kinase Don3 during mitosis and cytokinesis in Ustilago maydis. Mol. Microbiol. 62:655-666
  Sandrock, B., Böhmer, C. and Bölker, M.
  
• (2006) Essential role of Isd11 in ironsulfur cluster synthesis on Isu scaffold proteins. EMBO J. 25:184-195
  Wiedemann, N., Urzica, E., Guiard, B., Müller, H., Lohaus, C., Meyer, H.E., Ryan, M.T., Meisinger, C., Mühlenhoff, U., Lill, R., Pfanner, N.
  
• (2006) Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes. Biochim. Biophys. Acta 1763:652-667
  Lill, R., Dutkiewicz, R., Elsässer, H.P., Hausmann, A., Netz, D.J.A., Pierik, A.J., Stehling, O., Urzica, E., Mühlenhoff, U.
  
• (2007) A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis. Mol. Microbiol. 66:525-533
  Teichmann, B., Linne, U., Marahiel, M. A., Bölker, M.
  
• (2007) Coupling of protein localization & cell movements by a dynamically localized response regulator in Myxococcus xanthus. EMBO J. 26:433-4444
  Leonardy, S., Freymark, G., Hebener, S., Ellehauge, E., Søgaard-Andersen, L.
  
• (2007) Molecular characteristics of the Nipah virus glycoproteins. Ann. N.Y. Acad. Sci. 1102:39-50
  Diederich, S., Maisner, A.
  
• (2007) Proteomic analysis of dimorphic transition in the phytopathogenic fungus Ustilago maydis. Proteomics 7:675-685
  Böhmer, M., Colby, T., Böhmer, C., Bräutigam, A., Schmidt, J., Bölker, M.
  
• (2007) Structure of the yeast WD40 domain protein Cia1, a component acting late in ironsulfur protein biogenesis. Structure 15:1246-1257
  Srinivasan, V., Netz, D.J.A., Webert, H., Mascarenhas, J., Pierik, A.J., Michel, H., Lill, R.
  
• (2007) The Wiskott–Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila. Developmental Biology 304:664-674
  Schäfer, G., Weber, S., Holz, A., Bogdan, S., Schumacher, S., Müller, A., Renkawitz-Pohl, R., Filiz-Önel, S.
  
• (2007) Transport of nuclear-encoded proteins into secondarily evolved plastids. Biol. Chem. 388:899-906
  Hempel, F., Bozarth, A., Sommer, M.S., Zauner, S., Przyborski, J.M., Maier , U.G.
  
• (2007) Transport of nuclear-encoded proteins into secondarily evolved plastids. Biol. Chem. 388:899-906
  Hempel, F., Bozarth, A., Sommer, M.S., Zauner, S., Przyborski, J.M., Maier , U.G.
  
• (2008) An ancient look at UCP1. Biochim Biophys. Acta 1777:637-41
  Klingenspor, M., Fromme, T., Hughes, D.A. Jr, Manzke, L., Polymeropoulos, E., Riemann, T., Trzcionka, M., Hirschberg, V., Jastroch, M.
  
• (2008) Apical cargo traverses endosomal compartments on the passage to the cell surface. Traffic 9:2206-2220
  Cramm-Behrens, C.I., Dienst, M., Jacob, R.
  
• (2008) Cdc42 and the Ste20-like kinase Don3 act independently in triggering cytokinesis in Ustilago maydis. J. Cell Sci. 121:143- 148
  Böhmer, C., Böhmer, M., Bölker, M., Sandrock, B.
  
• (2008) Complex chloroplast RNA metabolism: Just debugging the genetic programme? BMC Biology 6:36
  Maier, U.G., Bozarth, A., Funk, H.T., Zauner, S., Rensing, S.A., Schmitz-Linneweber, C., Börner, T., Tillich, M.
  
• (2008) Control of cellular physiology by TM9 proteins in yeast and Dictyostelium. J Biol Chem 283:6764-72
  Froquet, R., Cherix, N., Birke, R., Benghezal, M., Cameroni, E., Letourneur, F., Mösch, H.- U., De Virgilio, C., Cosson, P.
  
• (2008) Ephrin-B2 expression critically influences Nipah virus infection independent of its cytoplasmic tail. Virol. J. 5:165
  Thiel, L., Diederich, S., Erbar, S., Pfaff, D., Augustin, H. G., Maisner A.
  
• (2008) Physical-chemical plant-derived signals induce differentiation in Ustilago maydis. Mol. Microbiol. 71:895-911
  Mendoza-Mendoza, A., Berndt, P., Djamei, A., Weise, C., Linne, U., Marahiel, M. Vranescaron, M., Kämper, J., Kahmann, R.
  
• (2008) PilB and PilT are ATPases acting antagonistically in type IV pilus function in Myxococcus xanthus. J. Bacteriol. 190:2411-2421
  Jakovljeic, V., Leonardy, S., Hoppert, M., Søgaard-Andersen, L.
  
• (2008) Regulated secretion of a protease activates intercellular signaling during fruiting body formation in M. xanthus. Dev. Cell. 15:627-634
  Rolbetzki, A., Ammon, M., Jakovljevic, V., Konovalova, A., Søgaard-Andersen, L.
  
• (2008) Reversing cells and oscillating motility proteins. Mol Biosyst 4:1009-1014
  Leonardy, S., Bulyha, I., Søgaard-Andersen, L.
  
• (2008) Reversing cells and oscillating motility proteins. Mol. Biosyst. 4:1009-1014
  Leonardy, S., Bulyha, I., Søgaard-Andersen, L.
  
• (2008) Role of endocytosis and cathepsin-mediated activation in Nipah virus entry. Virology 275:391-400
  Diederich, S., Thiel, L., Maisner, A.
  
• (2008) Selective receptor expression restricts Nipah virus infection of endothelial cells. Virol. J. 5:142
  Erbar, S., Diederich, S., Maisner, A.
  
• (2008) WASP and SCAR have distinct roles in activating the Arp2/3 complex during myoblast fusion. J. Cell Sci. 121:1303-1313
  Berger, S., Schäfer, G., Kesper, D.A., Holz, A., Eriksson, T., Palmer, R.H., Beck, L., Klämbt, C., Renkawitz-Pohl, R., Filiz-Önel, S.
  
• (2008) WASP and SCAR have distinct roles in activating the Arp2/3 complex during myoblast fusion. J. Cell Sci. 121:1303-1313
  Berger, S., Schäfer, G., Kesper, D.A., Holz, A., Eriksson, T., Palmer, R.H., Beck, L., Klämbt, C., Renkawitz-Pohl, R., Filiz-Önel, S.
  
• (2008). Ephrin-B2 expression critically influences Nipah virus infection independent of its cytoplasmic tail. Virol. J. 5:165
  Thiel, L., Diederich, S., Erbar, S., Pfaff, D., Augustin, H. G., Maisner A.
  
• (2008). Selective receptor expression restricts Nipah virus infection of endothelial cells. Virol. J. 5:142
  Erbar, S., Diederich, S., Maisner, A.
  
• (2009) A small molecule inhibitor of Nipah virus envelope protein-mediated membrane fusion. J. Med. Chem. 52:4257-4265
  Niedermeier, S., Singethan, K., Rohrer, S. G., Matz, M., Kossner, M., Diederich, S., Maisner, A., Schmitz, J., Baumann, K., Holzgrabe, U., Schneider-Schaulies, J.
  
• (2009) Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1. Biochemistry 48:4946-4958
  Urzica, E., Pierik, A.J., Mühlenhoff, U., Lill, R.
  
• (2009) Diatoms in biotechnology: tools and applications. Appl. Microbiol. Biotechnol. 82:195-201
  Bozarth A., Maier, U.G., Zauner, S.
  
• (2009) ERAD-derived Pre-Protein Transport across the 2nd Outermost Plastid Membrane of Diatoms. Mol Biol Evol. 26:1781-1790
  Hempel F., Bullmann L., Lau J., Zauner S., Maier U.G.
  
• (2009) ERAD-derived Pre-Protein Transport across the 2nd Outermost Plastid Membrane of Diatoms. Mol Biol Evol. 26:1781-1790
  Hempel F., Bullmann L., Lau J., Zauner S., Maier U.G.
  
• (2009) Protein Targeting into Secondary Plastids. J. Eukaryot. Microbiol. 56:9-15
  Bolte, K., Bullmann, L., Hempel, F., Bozarth, A., Zauner, S., Maier, U.G.
  
• (2009) Protein Targeting into Secondary Plastids. J. Eukaryot. Microbiol. 56:9-15
  Bolte, K., Bullmann, L., Hempel, F., Bozarth, A., Zauner, S., and Maier, U.G.
  
• (2009) Protein Targeting into Secondary Plastids. J. Eukaryot. Microbiol. 56:9-15
  Bolte, K., Bullmann, L., Hempel, F., Bozarth, A., Zauner, S., Maier, U.G.
  
• (2009) Protein Targeting into Secondary Plastids. J. Eukaryot. Microbiol. 56:9-15
  Bolte, K., Bullmann, L., Hempel, F., Bozarth, A., Zauner, S., Maier, U.G.
  
• (2009) Protein unfolding is an essential requirement for transport across the parasitophorous vacuolar membrane of Plasmodium falciparum. Mol. Microbiol. 71:613-628
  Gehde, N., Hinrichs, C., Montilla, I., Charpian, S., Lingelbach, K., Przyborski, J.M.
  
• (2009) Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte. Mol. Biochem. Parasitol. 167:48-53
  Bietz S., Montilla I., Külzer S., Przyborski J.M., Lingelbach K.
  
• (2009) Regulation of the type IV pili molecular machine by dynamic localization of two motor proteins. Mol. Microbiol. 74:691-706
  Bulyha, I., Schmidt, C., Lenz, P., Jakovljevic, V., Höne, A., Maier, B., Hoppert, M., Søgaard- Andersen, L.
  
• (2009) Return to sender: use of Plasmodium ER retrival sequences to study protein transport in the infected erythrocyte and predict putative ER protein families. Parasitology Research 104:1535-41
  Külzer, S., Gehde, N., Przyborski, J.M.
  
• (2009) Return to sender: use of Plasmodium ER retrival sequences to study protein transport in the infected erythrocyte and predict putative ER protein families. Parasitology Research 104:1535-41
  Külzer, S., Gehde, N., Przyborski, J.M.
  
• (2009) The dual specificity phosphatase Rok1 negatively regulates mating and pathogenicity in Ustilago maydis. Mol. Microbiol. 73:73-88
  Di Stasio, M., Brefort, T., Mendoza-Mendoza, A., Muench, K., Kahmann, R.
  
• (2009) The germinal centre kinase Don3 triggers the dynamic rearrangement of higher-order septin structures during cytokinesis in Ustilago maydis. Mol. Microbiol. 74:1484-1496
  Böhmer, C., Ripp, C., Bölker, M.
  
• (2010) Annexin XIIIb guids raftdependent and –independent apical traffic in MDCK cells. Eur. J. Cell Biol. 89:799-806
  Astanina, K., Delebinski, C., Delacour D., Jacob, R.
  
• (2010) Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metab. 12 :373-385
  Mühlenhoff, U., Molik, S., Godoy, J.R., Uzarska, M.A., Richter, N., Seubert, A., Zhang, Y., Stubbe, J., Pierrel, F., Herrero, E., Lillig, C.H., Lill, R.
  
• (2010) ERAD components in organisms with complex red plastids suggest recruitment of a preexisting protein transport pathway for the periplastid membrane. Genome Biol. Evol. 3:140-150
  Felsner, G., Sommer, M.S., Gruenheit, N., Hempel, F., Moog, D., Zauner, S., Martin, W., Maier, U.G.
  
• (2010) Filling the gap: the evolutionary conserved Omp85 in plastids of chromalveolates. J. Biol. Chem. 285:6848-6850
  Bullmann, L., Haarmann, R., Mirus, O., Bredemeier, R., Hempel, F., Maier, U.G., Schleiff, E.
  
• (2010) Filling the gap: the evolutionary conserved Omp85 in plastids of chromalveolates. J. Biol. Chem. 285:6848-6850
  Bullmann, L., Haarmann, R., Mirus, O., Bredemeier, R., Hempel, F., Maier, U.G., Schleiff, E.
  
• (2010) Filling the gap: the evolutionary conserved Omp85 in plastids of chromalveolates. J. Biol. Chem. 285:6848-6850
  Bullmann, L., Haarmann, R., Mirus, O., Bredemeier, R., Hempel, F., Maier, U.G., Schleiff, E.
  
• (2010) KIF5C, a kinesin motor involved in apical trafficking of MDCK cells. Cellular and Molecular Life Sciences 67:1331-1342
  Astanina, K., Jacob, R.
  
• (2010) New mechanistic insights into pre-protein transport across the second outermost plastid membrane of diatoms. Mol. Microbiol. 76:793-801
  Hempel, F., Felsner, G., Maier, U.G.
  
• (2010) New mechanistic insights into pre-protein transport across the second outermost plastid membrane of diatoms. Mol. Microbiol. 76:793-801
  Hempel, F., Felsner, G., Maier, U.G.
  
• (2010) Nipah virus infection and glycoprotein targeting in endothelial cells. Virology Journal 7:305-314
  Erbar, S. Maisner, A.
  
• (2010) Parasite-enclosed Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte. Cellular Microbiology 12: 1398-1420
  Külzer, S., Rug, M., Brinkmann, K., Cannon, P., Cowman, A., Lingelbach, K., Blatch G.L., Maier, A.G., Przyborski, J.M.
  
• (2010) Regulation of dynamic polarity in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J. 29:2276-2289
  Leonardy, S., Miertzschke, M., Bulyha, I., Sperling, E., Wittinghofer, A. Søgaard-Andersen, L.
  
• (2010) Regulation of dynamic polarity in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J. 29:2276-2289
  Leonardy, S., Miertzschke, M., Bulyha, I., Sperling, E., Wittinghofer, A. Søgaard-Andersen, L.
  
• (2010) Sho 1 and Msb2- related proteins regulate appressorium development in the Smut fungus Ustilago maydis. The Plant Cell 22:2085-2101
  Lanver, D., Mendoza-Mendoza, A., Brachmann, A., Kahmann, R.
  
• (2010) Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron. BMC Systems Biology 4:176
  Jungbluth, M., Renicke, C., Taxis, C.
  
• (2010) Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron. BMC Systems Biology 4:176
  Jungbluth, M., Renicke, C., Taxis, C.
  
• (2010) The AGC Ser/Thr kinase Aga1 is essential for appressorium formation and maintenance of the actin cytoskeleton in the smut fungus Ustilago maydis. Mol. Microbiol. 78:1484-1499
  Berndt, P., Lanver D., Kahmann, R.
  
• (2010) The AGC Ser/Thr kinase Aga1 is essential for appressorium formation and maintenance of the actin cytoskeleton in the smut fungus Ustilago maydis. Mol. Microbiol. 78:1484-1499
  Berndt, P., Lanver D., Kahmann, R.
  
• (2010) The C2H2 zinc finger transcription factor Rua1 activates the ustilagic acid biosynthesis gene cluster in Ustilago maydis. Appl. Environ. Microbiol. 76:2633-2640
  Teichmann, B., Liu, L, Schink, K.O., Bölker, M.
  
• (2010) The TEA transcription factor Tec1 confers promoter-specific gene regulation by Ste12- dependent and –independent mechanisms. Eukaryotic Cell 9:514-531
  Heise, B., van der Felden J., Kern, S., Malcher, M., Brückner, S., Mösch, H.-U.
  
• (2010) The TEA transcription factor Tec1 confers promoter-specific gene regulation by Ste12- dependent and –independent mechanisms. Eukaryotic Cell 9:514-531
  Heise, B., van der Felden, J., Kern, S., Malcher, M., Brückner, S., Mösch, H.-U.
  
• (2010) The TEA transcription factor Tec1 confers promoter-specific gene regulation by Ste12-dependent and -independent mechanisms. Eukaryotic Cell 9:514-531
  Heise, B., van der Felden J., Kern, S., Malcher, M., Brückner, S., Mösch, H.-U.
  
• (2010) Trafficking of galectin-3 through endosomal organelles of polarized and non-polarized cells. Eur. J. Cell Biol. 89:788-798
  Schneider, D., Greb C., Koch, A., Straube, T., Elli, A., Delacour, D., Jacob, R.
  
• (2010) Trafficking of galectin-3 through endosomal organelles of polarized and non-polarized cells. Eur. J. Cell Biol. 89:788-798
  Schneider, D., Greb C., Koch, A., Straube, T., Elli, A., Delacour, D., Jacob, R.
  
• (2010) Tyrosine residues in the cytoplasmic domains affect sorting and fusion activity of the Nipah virus Glycoproteins in polarized epithelial cells. J. Virol. 84:7634-7641
  Weise, C., Erbar, S., Lamp, B., Vogt, C., Diederich, S., Maisner, A.
  
• (2010) Tyrosine residues in the cytoplasmic domains affect sorting and fusion activity of the Nipah virus Glycoproteins in polarized epithelial cells. J. Virol. 84:7634-7641
  Weise, C., Erbar, S., Lamp, B., Vogt, C., Diederich, S., Maisner, A.
  
• (2010) Tyrosine residues in the cytoplasmic domains affect sorting and fusion activity of the Nipah virus Glycoproteins in polarized epithelial cells. J. Virol. 84:7634-7641
  Weise, C., Erbar, S., Lamp, B., Vogt, C., Diederich, S., Maisner, A.
  
• (2011) GTPases in bacterial cell polarity and signalling. Curr. Opin. Microbiol. 14, 726-733
  Bulyha, I., Hot, E., Huntley, S.; Søgaard-Andersen, L.
  
• (2011) GTPases in bacterial cell polarity and signalling. Curr. Opin. Microbiol. 14, 726-733
  Bulyha, I., Hot, E., Huntley, S.; Søgaard-Andersen, L.
  
• (2011) Mechanistic insights into bacterial polarity from structural analysis of the Ras-like G protein MglA and its cognate GAP MglB. EMBO J. 30, 4185-4197
  Miertzschke M., Koerner C., Vetter I.R., Keilberg D., Hot E., Leonardy S., Søgaard-Andersen L.; Wittinghofer A.
  
• (2011) Septation of infectious hyphae is critical for appressoria formation and virulence in the smut fungus Ustilago maydis. PLoS Pathog 7(5): e1002044
  Freitag, J., Lanver, D., Böhmer, C., Schink, K.O., Bölker, M., Sandrock, B.
  (See online at https://doi.org/10.1371/journal.ppat.1002044)
• (2011) Septation of infectious hyphae is critical for appressoria formation and virulence in the smut fungus Ustilago maydis. PLoS Pathog 7(5): e1002044
  Freitag, J., Lanver, D., Böhmer, C., Schink, K.O., Bölker, M., Sandrock, B.
  (See online at https://doi.org/10.1371/journal.ppat.1002044)
• (2011) Test systems to study the structure and function of uncoupling protein 1: a critical overview. Frontiers in endocrinology 2, 63
  Hirschberg, V., Fromme, T., and Klingenspor, M.
  
• (2011) The Multidomain Thioredoxin-Monothiol Glutaredoxins Represent a Distinct Functional Group. Antioxid. Redox Signal 15:19-30
  Hoffmann, B., Uzarska, M.A., Berndt, C., Godoy, J.R., Haunhorst, P., Lill, R., Lillig, Ch., Mühlenhoff, U.
  
• (2011) The Multidomain Thioredoxin-Monothiol Glutaredoxins Represent a Distinct Functional Group. Antioxid. Redox Signal 15:19-30
  Hoffmann, B., Uzarska, M.A., Berndt, C., Godoy, J.R., Haunhorst, P., Lill, R., Lillig, Ch., Mühlenhoff, U.
  
• (2011) The Yak1 protein kinase lies at the center of a regulatory cascade affecting adhesive growth and stress resistance in Saccharomyces cerevisiae. Genetics 187:717-730
  Malcher, M., Schladebeck, S., Mösch, H.-U.
  
• 2011) Chloroplast Omp85 proteins change orientation during evolution. Proc. Natl. Acad. Sci. USA, published ahead of print 8, 2011
  Sommer, M.S., Daum, B., Gross L.E., Weis, B.L.M., Mirus, O., Abram, L., Maier, U.G., Kühlbrandt, W., Schleiff, E.
  (See online at https://doi.org/10.1073/pnas.1108626108)
• (2012) Acetate regulation of spore formation is under the control of the Ras/Cyclic AMP/protein kinase A pathway and carbon dioxide in Saccharomyces cerevisiae. Euroryotic Cell 11
  Jungbluth, M., Mösch, H.-U., Taxis, C.
  (See online at https://doi.org/10.1128/EC.05240-11)
• (2012) Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment. J. Virol. 86, 3736- 3745
  Diederich, S., Sauerhering, L., Weis, M., Altmeppen, H., Schaschke, N., Reinheckel, T., Erbar, S., Maisner, A.
  (See online at https://doi.org/10.1128/JVI.06628-11)
• (2012) Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi. Letter
  Freitag, J, Ast, J., and Bölker, M.
  (See online at https://doi.org/10.1038/nature11051)
• (2012) Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi. Letter
  Freitag, J, Ast, J., and Bölker, M.
  (See online at https://doi.org/10.1038/nature11051)
• (2012) Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts. Journal of Cell Science 113860, Online September 19
  Kaipa, B.R., Shao, H., Schäfer, G., Trinkewitz, T., Groth, V., Liu, J., Beck, L., Abmayr, S.M. and Filiz-Önel, S.
  (See online at https://doi.org/10.1242/jcs.113860)
• (2012) Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak., Biochimica et biophysica acta 1817, 1660- 1670
  Jastroch, M., Hirschberg, V., and Klingenspor, M.
  (See online at https://doi.org/10.1016/j.bbabio.2012.05.014)
• (2012) Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. Developmental Biology 370:86-97
  Susic-Jung, L., Hornbruch-Freitag, C., Kuckwa, J. Rexer, K.-H., Lammel, U., and Renkawitz-Pohl, R.
  (See online at https://doi.org/10.1016/j.ydbio.2012.07.022)
• (2012) Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. Developmental Biology 370:86-97
  Susic-Jung, L., Hornbruch-Freitag, C., Kuckwa, J. Rexer, K.-H., Lammel, U., and Renkawitz-Pohl, R.
  (See online at https://doi.org/10.1016/j.ydbio.2012.07.022)
• (2012) Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. Developmental Biology 370:86-97
  Susic-Jung, L., Hornbruch-Freitag, C., Kuckwa, J. Rexer, K.-H., Lammel, U., and Renkawitz-Pohl, R.
  (See online at https://doi.org/10.1016/j.ydbio.2012.07.022)
• (2012) Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia. PNAS 109:16864- 16869
  Maestre-Reyna, M., Diderrich, R., Veelders, M.S., Eulenburg, G., Kalugin, V., Brückner, S., Keller, P., Rupp, S., Mösch, H.-U., Essen, L.-O.
  (See online at https://doi.org/10.1073/pnas.1207653109)
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