Peptide models for generation and control of multivalent interactions (A05)

• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation ; Inorganic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2008 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32049920

The concepts that have been optimized in previous work will now be applied to scientific problems of biological relevance. Subproject 1 is dedicated to the development of short peptidic scaffolds that exploit aromatic and unnatural amino acids to promote their own self-organization and present virus-binding and other ligands in a multivalent fashion. In subproject 2 various coiled coil-based glycopeptides will be developed for the purpose of elucidating structurally under-investigated yet immunologically relevant CTL-Receptors and their cross-talk. Knowledge gained from both of these subprojects will be used to develop diagnostic assays.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 765: Multivalency as Chemical Organisation and Action Principle: New Architectures, Functions and Applications
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professorin Dr. Beate Koksch, since 4/2015; Professorin Dr. Sabine Schlecht, until 5/2009