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Projekt Druckansicht

Interaction of bacterial actin-like proteins with the cell membrane

Fachliche Zuordnung Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
Förderung Förderung von 2008 bis 2015
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 43311986
 
Erstellungsjahr 2016

Zusammenfassung der Projektergebnisse

Prior to the project outlined above, it had become clear that MreB interacts with several membrane proteins that are required for cell wall synthesis and for the maintenance of rod shape, in many different bacteria, including B. subtilis. Within the scope of FOR 929, we were able to show that B. subtilis MreB does not form a continuous helical structure, as was proposed in earlier work by other groups, but discontinuous extended filaments that move in varying angles around 90° and in both directions underneath the cell membrane. Most likely, entire filaments move, rather than actin-like tread milling, and filaments can coordinate the movement of cell wall synthesis enzymes across the diameter of the cell, i.e. over a distance of 1.7 µm or more, which may stabilize the formation of rod shaped cells. We have also efficiently collaborated with several other groups of the consortium, and have introduced bacterial cell biology to several groups in Freiburg, generating a powerful combination of existing expertise in biochemistry with cell biology, to better understand dynamics of proteins at and within bacterial membranes.

Projektbezogene Publikationen (Auswahl)

 
 

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