Detailseite
Projekt
Dissecting cell fate regulation in USSC
Antragsteller
Professor Dr. Peter Wernet
Fachliche Zuordnung
Hämatologie, Onkologie
Förderung
Förderung von 2007 bis 2011
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 20803802
According to their pluripotent developmental capacity unrestricted somatic stem cells (USSC)are an intriguing system to analyze mechanisms defining pluripotency or regulating themaintenance, the specification and realization of different cell fates, respectively. Thescientific aim of our group is to obtain gene expression and microRNA signatures of USSCand their derivatives and to compare them with corresponding signatures of human embryonicstem cell lines. At the basis of these signatures we like to identify transcription factors as wellas microRNAs, which are functionally associated with the pluripotent state of USSC andothers, which are functionally involved in controlling the decision process of self-renewalversus differentiation of USSC. By over-expression as well as by loss of function experimentswe will analyze the impact of identified candidates on these processes and aim to define anepistatic cascade of factors governing self-renewal, pluripotency, and distinct lineagecommitment of USSC.
DFG-Verfahren
Forschungsgruppen
Beteiligte Personen
Professor Dr. Bernd Giebel; Dr. Hans-Ingo Trompeter
