Integration of selective separation techniques for the continuous reuse of deep eutectic solvents

• Applicant: Professor Dr. Jan von Langermann
• Subject Area: Biological Process Engineering ; Technical Chemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 528814716

The primary goal of this subproject SP6 is the direct integration of downstream processing into DES-based biocatalytic processes. The focus lies on the use of crystallization- as well as adsorber/ion exchanger-based solutions with an emphasis on the selective separation of the desired product from the reaction mixture. This requires not only the definition of suitable, novel DES but also a further understanding of the physical-chemical relationships of the DES during the separation step, whereby both in situ as well as classic downstream processing process steps are considered. Transaminase-, amine dehydrogenase and decarboxylase-catalyzed catalysts will be used as model systems, which will be investigated in detail in coordination with the other subprojects. This will be investigated in detail in different process variants (batch, fed-batch, repetitive batch, etc.). This includes the use of novel biocatalysts as well as tailor-made DES-based reaction mixtures, which will be provided by the project partners. The overall aim of this sub-project is specifically the eventual recovery of DES solvent systems at or close to the initial state (before the underlying biocatalytic process) to enable simple reuse without significant additional process steps.

• DFG Programme: Research Units
• Subproject of: FOR 5730: Customized Deep Eutectic Solvents for Biocatalysis – a circular approach from molecular interactions to process parameters – (DESMOL2PRO)