FOR 440:  Prevention of Ischemia Reperfusion Injury

• Subject Area: Medicine
• Term: from 2001 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5468499

Temporary reduction or loss of perfusion of solid organs induces ischemia reperfusion injuries (IRI). IRI can severely impare organ function and thus are dangerous side-effects of surgical (resection, transplantation) as well as medical (coronary dilatation) interventions. IRI are main factors of organ shortage in liver transplantation by induction of non-function or severe dysfunction after transplantation and by preventing the use of sligthly damaged organs. Therefore, aim of the interdisciplinary research unit is the implementation of new avenues of prevention of IRI of liver, heart and pancreas. This includes characterization of pivotal pathomechanisms of IRI and the influence of prevention. Transfer to patient care including prospective randomized controlled trials is an essential part of the programme. The new strategies comprise hormonal and ischemic preconditioning and the postischemic application of glutathione.

• DFG Programme: Research Units

Projects

• Bedeutung von Mikropartikeln für den Ischämie-Reperfusionsschaden (Applicant Engelmann, Bernd )
• Characterization of the role of p38 mitogen-activated protein kinase in hormonal preconditioning of livers with atrial natural natriuretic peptide (Applicant Kiemer, Alexandra K. )
• Impact of ischemic temperature on the initial cellular and molecular mechanisms of hepatic ischemia-reperfusion injury (Applicant Krombach, Fritz )
• Klinische Studie zur Therapie des Reperfusionsschadens bei akutem Myokardinfarkt (Applicant Boekstegers, Peter )
• Pharmakologische Inaktivierung der Kupffer-Zellen und Transplantation von Neo-Hepatozyten - Bedeutung für die Prävention und Reparatur des Ischämie-Reperfusionsschadens in Fettlebern (Applicant Bilzer, Manfred )
• Präkonditionierung und Pankreatitis. Effekt und Mechanismen der Protektion durch hormonelle Präkonditionierung mit ANP und Präkonditionierung mit Hyperthermie (Applicant Wagner, Andreas )
• Selektive Hemmung des Transkriptionsfaktors NF-kB in Kupfferzellen - Bedeutung für den Ischämie-Reperfusionsschaden der Leber (Applicant Vollmar, Angelika )
• Therapeutische Beeinflussbarkeit des endothelabhängigen Ischämie-Reperfusions-Schadens des Herzens (Applicant Kupatt, Christian )
• Therapie nach transienter zerebraler Ischämie und Reperfusion - Was sind die protektiven Mechanismen der Hypothermie? (Applicant Hamann, Gerhard Ferdinand )
• Zentrale Funktionen (Applicant Gerbes, Alexander L. )

• Spokesperson: Professor Dr. Alexander L. Gerbes