Metagenomics in emerging viral infections – integrating non-host and host transcriptional responses (D02)

• Subject Area: Virology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711

The project seeks to advance pathogen detection through metagenomic and metatranscriptomic methods, refining next-generation sequencing approaches. It involves cataloging microbial and host-derived sequences, creating expression signatures for specific diagnostic entities, and developing host signatures for viral families. Leveraging expertise in viral genomics, the project integrates nucleotide sequence-independent methods for pathogen detection. Furthermore, it aims to predict infectious diseases by analyzing disease-associated host responses, addressing challenges posed by unknown pathogens like "Disease X".

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1648: Emerging Viruses: Pathogenesis, Structure, Immunity
• Applicant Institution: Universität Hamburg
• Project Head: Professorin Dr. Nicole Brigitte Fischer