Multidimensional analysis of protective and damaging adaptive immune responses in emerging viral infections (C04)

• Subject Area: Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711

The ability to quickly analyze host immune response patterns to novel viral infections and mechanisms of immune evasion are key for pandemic preparedness. Thus, we focus on analyzing host immune responses to emerging viruses. We hypothesize that initial naïve adaptive immune responses, while aiding in pathogen clearance, might lead to hyperinflammation or autoimmune-like reactions. Additionally, we aim to examine the switch from innate to adaptive immunity, especially in immunocompromised and re-infected vaccinated patients to gain insights into immune dynamics.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1648: Emerging Viruses: Pathogenesis, Structure, Immunity
• International Connection: Switzerland
• Applicant Institution: Universität Hamburg
• Project Heads: Professorin Mascha Binder, Ph.D.; Professor Dr. Julian Schulze zur Wiesch