Characterization of host factors as targets for the development of broadly acting therapeutics against emerging viruses (B02)

• Subject Area: Virology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711

Specific treatments remain rare for emerging viruses, but approaches targeting conserved virus-host interactions have the potential to yield broadly active therapies capable of targeting a diverse range of disease agents (including novel viruses). We have identified promising virus-host interactions based on siRNA screening against genetically diverse pathogens (i.e. filoviruses and arenavirus). We now plan to investigate in-depth the details of their role in virus infection and define their molecular interactions with viral components as a first step in realizing the therapeutic potential of these targets.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1648: Emerging Viruses: Pathogenesis, Structure, Immunity
• Applicant Institution: Universität Hamburg
• Project Heads: Privatdozentin Allison Groseth, Ph.D.; Privatdozent Dr. Thomas Hoenen