Neuronal response to emerging viral infections (A03)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases ; Immunology ; Virology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711

Many emerging viral infections (EVIs) cause direct encephalitis or cytokine storm-mediated encephalopathy. Host-pathogen co-evolution has shaped immune gene selection, but prolonged innate immune responses in organs like the brain are detrimental. Interferon-stimulated genes (ISGs), including apolipoprotein L family members, are balanced between infection containment and neuronal toxicity. Understanding this interplay offers translational potential for innovative approaches in treating EVI-associated neurological sequelae.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1648: Emerging Viruses: Pathogenesis, Structure, Immunity
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Manuel A. Friese