Project Details
Projekt
Humanized mice to study the zoonotic potential and pathophysiology of hepatotropic emerging pathogens (A02)
Subject Area
Virology
Immunology
Immunology
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711
A number of emerging viruses have been associated with liver disease, including new hepatitis B-like viruses from bats, and other not strictly hepatotropic viruses such as EBOV, DENV and YFV. We hypothesize that the capacity of emerging viruses to replicate in liver cells impacts pathophysiology and disease outcome. We will develop and use distinct humanized and chimeric mouse models to understand zoonotic potential, hepatotropism and pathophysiology of these viruses, and establish models to study yet unknown emerging pathogens (Pathogen ‘X’).
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professorin Dr. Maura Dandri; Privatdozentin Estefania Rodriguez
