Detailseite
Projekt
Infiltration, migration and function of leukocytes in trauma-induced immunomodulation and the involvement of Heat-Shock Proteins
Antragstellerin
Professorin Dr. Stefanie Flohé
Fachliche Zuordnung
Orthopädie, Unfallchirurgie, rekonstruktive Chirurgie
Förderung
Förderung von 2003 bis 2012
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5407835
Polytraumatised patients develop a generalised inflammatory syndrome in the absence of bacterial infections. In parallel it can be determined that certain cellular immunological functions in severely traumatised are downregulated. The factors responsible for these phenomena have not yet been well characterised. Since heat shock proteins (HSP) are supposed to get liberated from their intracellular localisation during tissue destruction and some of these proteins possess a high potential to activate inflammatory cells HSP might be involved in the inflammatory state occurring after severe trauma. The involvement of HSP in posttraumatic inflammatory reactions will be examined in the blood of polytrauma patients and wound fluid of patients undergoing elective surgery of different severity. Furthermore, the role of HSP will be studied in experimental murine trauma models and in cell cultures. The emphasis of the planned investigation is on biochemical and molecular biological methods.
DFG-Verfahren
Schwerpunktprogramme
Beteiligte Person
Professor Dr. Fritz Ulrich Schade
