Synthesis and investigation of polypeptide rod-coil block copolymers for nanostructured materials

• Antragsteller: Professor Dr. Henning Menzel
• Fachliche Zuordnung: Präparative und Physikalische Chemie von Polymeren
• Förderung: Förderung von 2003 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5400360

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

The combination of nickel mediated NCA polymerization and living radical polymerization by ATRP, NMP and RAFT is possible using bifunctional initiators. The principle advantage of the approach is that larger polypeptide blocks can be prepared and different and more polar monomers can be introduced into the block copolymer. However, there are some obstacles which still have to be overcome. The macroinitiators in particular those for the ATRP have a significantly reduced activity, therefore only short blocks of flexible polymers can be added, which do not influence the properties of the block copolymers strongly. For shorter polypeptide blocks the amine initiated NCA synthesis is more appropriate and easier to do. Gradient polymer elution chromatography is a very critical method to evaluate the synthetic processes and a better access to this method is crucial for further development of the synthetic methods. Poly(benzyl-L-glutamate) shows an interesting thermoreversible gelation and even below the critical gelation concentration aggregates of the polymer can be found. The same aggregation is found for the block copolymers with relatively long peptide blocks and short PMMA or PtBA blocks. Since so far no block copolymers with longer flexible chains have been investigated, it is not yet clear whether this will change the aggregation behavior.

Projektbezogene Publikationen (Auswahl)

• Macromol. Symp. 248, 199 -206 (2007) "Synthesis of rod-coil block copolymers using two controlled polymerization techniques"
  S. Steig, F. Cornelius, A. Heise, R. J. I. Knoop, G. J. M. Habraken, C. E. Koning, H. Menzel
  
• J. Polym. Sci. A., Polym. Chem. Ed. 46, 3068-3077 (2008) "Synthesis of Poly(benzyl glutamate-b-styrene) Rod-Coil Block Copolymers by Dual Initiation in One Pot"
  R. J. I. Knoop, G. J. M. Habraken, N. Gogibus, S. Steig, H. Menzel, C. E. Koning, A. Heise
  
• Macromol. Symp. 275-276, 67-72 (2009) "Synthesis of Polypeptide Based Rod-Coil Block Copolymers by Using TEMPO Based Bifunctional Initiator"
  M. Stern, S. Jurejevic, A. Heise, H. Menzel
  
• Macromol. Symp. 275-276, 82-89 (2009) "One-Pot Procedure for the Preparation of Rod-Coil Block Copolymers via a Bifunctional Initiator"
  Niehoff, S. Jurejevic, A. Heise, H. Menzel
  
• Macromolecules 43, 4126-4132 (2010) "Stimuli responsive peptide bioconjugated polymer nanoparticles"
  R. J. I. Knoop, M. de Geus, G. J. M. Habraken, M. de Geus, C. E. Koning, H. Menzel, A. Heise