Project Details
Projekt
KFO 114: TULIP: Tuebingen Lifestyle Intervention Programme Prevention of type 2 diabetes mellitus and its vascular complications - identification of predictive metabolic and genotypic parameters for the responsiveness to and necessity for lifestyle intervention
Subject Area
Medicine
Biology
Biology
Term
from 2003 to 2009
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5396893
The medical and socioeconomic importance of primary prevention of type 2 diabetes mellitus is unquestionable. Approximately one third of the German population is predisposed to this disease. Practical implementation of prevention programmes within available resources therefore requires validated predictors for both disease risk and responsiveness to preventive measures. In the Tübingen family study, first degree relatives of patients with type 2 diabetes were characterized for prediabetic subphenotypes. Based on a database of over 1000 phenotypically and genotypically characterized subjects we start a longitudinal study in 400 non-diabetic (NGT or IGT), overweight volunteers (recruitment over 3 years) who undergo a structured lifestyle modification (low calory diet plus exercise).
In retrospective analyses metabolic (insulin secretion and sensitivity, respiratory quotient, fatty acid pattern, adipocytokine concentrations) and genotypic markers (candidate gene variants) at baseline shall be identified that predict the necessity for and responsiveness to prevention (change in body weight and glucose tolerance as surrogate endpoint). With refined subprotocols (insulin sensitivity of the central nervous system, intramyocellular lipids, short-term lipid infusion, insulin secretion and sensitivity at follow up) that can be carried out as add-ons to the main longitudinal protocol, insight into mechanisms of disease development and prevention can be obtained. Results from these add-on protocols in turn may contribute to develop novel concepts (e.g. candidate genes) that can be validated using the main protocol cohort. By coupling laborious clamps to simple test (for use in daily routine) the expected findings may be used for designing multicentre prevention trials or directly translated into preventive medicine.
In retrospective analyses metabolic (insulin secretion and sensitivity, respiratory quotient, fatty acid pattern, adipocytokine concentrations) and genotypic markers (candidate gene variants) at baseline shall be identified that predict the necessity for and responsiveness to prevention (change in body weight and glucose tolerance as surrogate endpoint). With refined subprotocols (insulin sensitivity of the central nervous system, intramyocellular lipids, short-term lipid infusion, insulin secretion and sensitivity at follow up) that can be carried out as add-ons to the main longitudinal protocol, insight into mechanisms of disease development and prevention can be obtained. Results from these add-on protocols in turn may contribute to develop novel concepts (e.g. candidate genes) that can be validated using the main protocol cohort. By coupling laborious clamps to simple test (for use in daily routine) the expected findings may be used for designing multicentre prevention trials or directly translated into preventive medicine.
DFG Programme
Clinical Research Units
Projects
- Bedeutung der Insulinsensitivität des ZNS in der Pathogenese und in der Prävention des Diabetes mellitus Typ 2 (Applicant Fritsche, Andreas )
- Charakterisierung des Betazellversagens (Applicant Fritsche, Andreas )
- Einfluß einer Lebensstil- und Ernährungsmodifikation auf endotheliale Dysfunktion und Intima-Media-Dicke bei Insulinresistenz (Applicant Balletshofer, Bernd )
- Fettsäuremuster, Fettbelastung und Adipozytokine (Applicant Schleicher, Erwin )
- Insulin Signaling und neuronale Aktivität im Mausmodell (Applicant Hennige, Anita M. )
- Körperfettkompartimente und assoziierte Stoffwechselaktivitäten - Verlauf während diätetischer und sportlicher Therapie - Erfassung von prädiktiven Fettverteilungsmustern (Applicant Schick, Fritz )
- Prävention des Typ 2 Diabetes und seiner Gefäßkomplikationen - Identifizierung metabolischer und genotypischer Merkmale zur Voraussage von Notwendigkeit und Ansprechen präventiver Maßnahmen (Applicant Häring, Hans-Ulrich )
Spokesperson
Professor Dr. Hans-Ulrich Häring
