Charakterisierung von antimikrobiellen Effektormechanismen in humanen Endothelzellen nach Stimulation mit Interferon

• Antragsteller: Professor Dr. Walter Däubener
• Fachliche Zuordnung: Parasitologie und Biologie der Erreger tropischer Infektionskrankheiten
• Förderung: Förderung von 2002 bis 2016
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5388644

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Antimicrobial and immunoregulatory effects mediated by human lung cells. FEMS 52:273-28
  K. Heseler, S. Stuhlsatz, C. Woite, C.R. MacKenzie and W. Däubener
  
• Human bone marrow stromal cells inhibit allogeneic T-cell responses by indolamine 2,3-dioxygenase mediated tryptophan degradation. Blood 103: 4619-4621
  R. Meisel, A. Zibert, M. Laryea, U. Göbel, W. Däubener and D. Dilloo
  
• Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indolamine 2,3-dioxygenase. Microbes and Infection 6: 806-812
  O. Adams, K. Besken, C. Oberdörfer, C.R. MacKenzie, D. Rüßing and W. Däubener
  
• Inhibition of the growth of Toxoplasma gondii in immature human dendritic cells is dependent on the expression of TNF-a receptor2. J. Immunology 173: 3366-3374
  A. Giese, W. Däubener and C.R. MacKenzie
  
• Nitric oxidemediated regulation of gamma interferon-induced bacteriostasis: Inhibiition and degradation of human indolamine 2,3-dioxygenase. Infection and Immunity 72: 2723-2730
  C. Hucke, C.R. MacKenzie, K.D.Z. Adjogble, O. Takikawa and W. Däubener
  
• Porcine choroids plexus epithelial cells induce streptococcus suis bacteriostasis in vitro. Infect. Immun. 72:3084-3087
  R.A. Adam, T. Tenenbaum, P. Valentin-Weigand, M. Laryea, B. Schwahn, S. Angelow, H.J. Galla, W, Däubener and H. Schroten
  
• Role of indolamine 2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections. J. Virology 78:2632-2636
  O. Adams, K. Besken, C. Oberdörfer, CR. MacKenzie, O. Takikawa and W. Däubener
  
• J. Virology 79: 7768-7776
  K. Obojes, O. Andres, K. S. Kim, W. Däubener and J. Schneider-Schaulies
  
• Role of human brain microvascular endothelial cells during central nervous system infection. Thrombosis and Haemostasis 94: 341-346
  R. A. Adam, D. Rüßing, O. Adams, C Woite, H. Schroten and W. Däubener.
  
• Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immunoregulation: tryptophan depletion versus production of toxic kynurenines. Current Drug Metabolism 8:237-244
  C.R. MacKenzie, Kathrin Heseler, Anika Müller and W. Däubener
  
• Antimicrobial and immunoregulatory effector mechanisms in human endothelial cells. Thrombosis and Haemostasis. 102: 1110-1116
  W. Däubener, K.S. Schmidt, K. Heseler and C.R. MacKenzie
  
• Antimicrobial and immunoregulatory properties of human tryptophan 2,3- dioxygenase. Eur. J. Immunology. 29: 275-2764
  S.K. Schmidt, A. Müller, K. Heseler, C Woite, K. Spekker, CR. MacKenzie and W. Däubener
  
• Indoleamine 2,3-dioxygenase is involved in the defense against Neospora caninum in human and bovine cells. Infection and Immunity, 77: 4496-4501
  K. Spekker, M. Czesla, V. Ince, K. Heseler, S.K. Schmidt, G. Schares and W. Däubener
  
• The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects. J. Cell. MoJ. Med. 13: J125-1135
  A. Müller, K. Heseler, S.K. Schmidt, K. Spekker, CR. MacKenzie and W. Däubener