Die Rolle von UL128-131-abhängigen Endozytosemechanismen für den Endothelzelltropismus des menschlichen Cytomegalovirus (HCMV)

• Antragsteller: Professor Dr. Christian Sinzger
• Fachliche Zuordnung: Virologie
• Förderung: Förderung von 2002 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5388628

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• 2004. Genetic content of wild-type human cytomegalovirus. J Gen Virol 85, 1301-12
  Dolan, A., Cunningham, C., Hector, R.D., Hassan-Walker, A.F., Lee, L., Addison, C., Dargan, D.J., McGeoch, D.J., Gatherer, D., Emery, V.C., Griffiths, P.D., Sinzger, C., McSharry, B.P., Wilkinson, G.W. and Davison, A.J.
  
• 2005. Downregulation of natural killer cell-activating ligand CDl55 by human cytomegalovirus UL141. Nat Immunol 6, 181-8
  Tomasec, P., Wang, E.C., Davison, A.J., Vojtesek, B., Armstrong, M., Griffin, C., McSharry, B.P., Morris, R.J., Llewellyn-Lacey, S., Rickards, C., Nomoto, A., Sinzger, C. and Wilkinson, G.W.
  
• 2005. Human cytomegalovirus labeled with green fluorescent protein for live analysis of intracellular particle movements. J Virol 79, 2754-67
  Sampaio, K.L., Cavignac, Y., Stierhof, Y.D. and Sinzger, C.
  
• (2006). Determinants of Endothelial Cell Tropism of Human Cytomegalovirus. In Cytomegaloviruses: Molecular Biology and Immunology, pp. 445-464. Edited by R. M. J. Norfolk: Caister Academic Press
  Digel, M. & Sinzger, C
  
• 2006. Evidence for direct transfer of cytoplasmic material from infected to uninfected cells during cell-associated spread of human cytomegalovirus. J Clin Virol 37, 10-20
  Digel, M., Sampaio, K.L., Jahn, G. and Sinzger, C.
  
• 2006. Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMV. J Virol 80, 11539-55
  Bentz, G.L., Jarquin-Pardo, M., Chan, G., Smith, M.S., Sinzger, C. and Yurochko, A.D.
  
• 2006. Human cytomegalovirus subverts the functions of monocytes, impairing chemokine-mediated migration and leukocyte recruitment. J Virol 80, 7578-89
  Frascaroli, G., Varani, S., Moepps, B., Sinzger, C, Landini, M.P. and Mertens, T.
  
• 2006. Macrophage cultures are susceptible to lytic productive infection by endothelial-cellpropagated human cytomegalovirus strains and present viral lEl protein to CD4+ T cells despite late downregulation of MHC class II molecules. J Gen Virol 87, 1853-62
  Sinzger, C., Eberhardt, K., Cavignac, Y., Weinstock, C., Kessler, T., Jahn, G. and Davignon, J.L.
  
• 2006. Role of human cytomegalovirus UL131A in cell type-specific virus entry and release. J Gen Virol 87, 2451-60
  Adler, B., Scrivano, L., Ruzcics, Z., Rupp, B., Sinzger, C. and Koszinowski, U.
  
• 2007. Effect of serum and CTL on focal growth of human cytomegalovirus. J Clin Virol 38, 112-9
  Sinzger, C., Mangin, M., Weinstock, C., Topp, M.S., Hebart, H., Einsele, H. and Jahn, G.
  
• 2008. Charge cluster-to-alanine scanning of UL128 for fine tuning of the endothelial cell tropism of human cytomegalovirus. J Virol 82, 11239-46
  Schuessler, A., Sampaio, K.L. and Sinzger, C.
  
• 2008. Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E. J Gen Virol 89, 359- 68
  Sinzger, C., Hahn, G., Digel, M., Katona, R., Sampaio, K.L., Messerle, M., Hengel, H., Koszmowski, U., Brune, W. and Adler, B.
  
• 2008. Cytomegalovirus cell tropism. Curr Top Microbiol Immunol 325, 63-83
  Sinzger, C., Digel, M. and Jahn, G.
  
• 2008. Entry route of HCMV into endothelial cells. J Clin Virol 41, 174-9
  Sinzger, C.
  
• 2008. UL74 of human cytomegalovirus contributes to virus release by promoting secondary envelopment of virions. J Virol 82, 2802-12
  Jiang, X.J., Adler, B., Sampaio, K.L., Digel, M., Jahn, G., Ettischer, N., Stierhof, Y.D., Scrivano, L., Koszinowski, U., Mach, M. and Sinzger, C.
  
• 2009. Endothelial cells in human cytomegalovirus infection: one host cell out of many or a crucial target for virus spread? Thromb Haemost 102, 1057-63
  Adler, B. and Sinzger, C