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Effects of chemokine signalling on microglial physiology: An electrophysiological and molecular biological approach
Antragsteller
Professor Dr. Helmut Kettenmann
Fachliche Zuordnung
Molekulare Biologie und Physiologie von Nerven- und Gliazellen
Förderung
Förderung von 2002 bis 2006
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5378625
Erstellungsjahr
2006
Zusammenfassung der Projektergebnisse
The research project has yielded several novel conclusions: 1) Our suggestion that CCL21 is involved in neuronal-microglial signalling has been confirmed both in vivo and in vitro. 2) CXCR3 is present and functional in human microglia, this finding shows the clinical relevance of the project. 3) The Groningen lab have recently shown that CCL21 in neurons is packed in vesicles and can be released, probably at nerve endings. This may be a good explanation for neurodegenerative/ neuroinflammatory processes at distance from a lesion. In total, it was a very successful collaboration and it is still going on.