Functional characterization of DNA methylation in Drosophila

• Antragsteller: Professor Dr. Frank Lyko
• Fachliche Zuordnung: Allgemeine Genetik und funktionelle Genomforschung
• Förderung: Förderung von 2002 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5370376

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2003). A Dnmt2-like protein mediates DNA methylation in Drosophila. Development 130, 5083-5090
  Kunert, N., Marhold, J., Stanke, J., Stach, D., and Lyko, F.
  
• (2004). Conservation of DNA methylation in dipteran insects. Insect Mol. Biol. 13, 117-123
  Marhold, J., Rothe, N., Pauli, A., Mund, C, Kuehle, K., Brueckner, B., and Lyko, F.
  
• (2004). DNA methylation in insects. Insect Mol. Biol. 13, 109-115
  Field, L.M., Lyko, F., Mandrioli, M., and Prantera, G.
  
• (2005). Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi. Nucleic Acids Res. 33,6405-6417
  uhlmann, M., Borisova, B.E., Kaller, M., Larsson, P., Stach, D., Na, J., Eichinger, L., Lyko, F., Ambros, V., Söderbom,. F., Hammann, C., and Nellen, W.
  
• (2006). Two substrates are better than one: dual specificities for Dnmt2 methyltransferases. Trends Biochem. Sci. 31, 306-308
  Jeltsch, A., Nellen, W., and Lyko, F.
  
• (2007). DNA methylation with a sting: An active DNA methylation system in the honeybee. Bioessays 29, 208-211
  Schaefer, M., and Lyko, F.
  
• (2007). Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445, 671-675
  Barreto, G., Schäfer, A., Marhold, J., Stach, D., Swaminathan, S.K., Handa, V., Doderlein, G., Maltry, N., Wu, W., Lyko, F., and Niehrs, C.
  
• (2008). The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis. PLoS ONE 3, e1414
  Schaefer, M., Steringer, J.P., and Lyko, F.
  
• (2008). Use of DNAzymes for sitespecific analysis of ribonucleotide modifications. RNA 14. 180-187
  Hengesbach, M., Meusburger, M., Lyko, F., and Helm, M.
  
• (2009). RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res. 37, e12
  Schaefer, M., Pollex, T., Hanna, K., and Lyko, F.