Molekulare Analyse von Proteinkomplexen, die an der Signalübertragung zum Aktinzytoskelett beteiligt sind

• Antragstellerin: Professorin Dr. Theresia Stradal
• Fachliche Zuordnung: Zellbiologie
• Förderung: Förderung von 2002 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5469361

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2004) Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nat Cell Biol., 6, 319-327
  Innocenti, M., Zucconi, A., Disanza, A., Frittoli, E., Areces, L. B., Steffen, A., Stradal, T. E., Di Fiore, P. P., Carlier, M. F., and Scita, G.
  
• (2004) Eps8 controls actinbased motility by capping the barbed ends of actin filaments. Nature Cell Biol., 6, 1180-1188
  Disanza, A., Carlier, M.F., Stradal, T.E.B., Didry, D., Frittoli, E., Confalonieri, S., Croce, A., Wehland, J., Di Fiore, P.P., and Scita, G.
  
• (2004) Regulation of actin dynamics by WASP and WAVE family proteins. Trends Cell Biol 14, 303-311
  Stradal, T. E., Rottner, K., Disanza, A., Confalonieri, S., Innocenti, M., and Scita, G.
  
• (2005) Aktindynamik und WASP/WAVE-Proteine. Biospektrum, 11(3), 283-286
  Stradal, T.E.B., Wehland, J.
  
• (2005) PREL1 links Ras signalling to actin remodelling via Ena/VASP proteins. FEBS Lett., 579, 455–463
  Jenzora, A., Behrendt, B.,Small, J.V., Wehland, J., and Stradal, T.E.B.
  
• (2005) Vinculin acts as a sensor in lipid regulation of adhesion site turnover. J. Cell Sci., 118, 1461-1472
  Chandrasekar, I., Stradal, T.E.B., Holt, M.R., Entschladen, F., Jockusch, B.M., and Ziegler W.H.
  
• (2005). Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement. Cell Mol Life Sci., 62, 955-970
  Disanza, A., Steffen, A., Hertzog, M., Frittoli, E., Rottner, K., and Scita, G.
  
• (2006) Molecular regulation of cytoskeletal rearrangements during T cell signalling. In: Results and Problems in Cell Differentiation (RPCD); Volume: Cell Communication in Nervous and Immune System (eds. B. Schraven & E. Gundelfinger), Springer Verlag, Berlin, 43, pp 219-44
  Stradal, T.E.B., Pusch, R., and Kliche S.
  
• (2006) Protein complexes regulating cellular actin assembly. Curr. Op. Cell Biol., 18, 4-10
  Stradal, T.E.B., and Scita, G.
  
• (2006) The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc. Natl. Acad. Sci. U. S. A., 103(20), 7694-7699
  Schirenbeck A, Arasada R, Bretschneider T, Stradal TE, Schleicher M, Faix J
  
• (2007) c-Met is essential for wound healing in the skin. J. Cell Biol., 177(1), 151-162
  Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T.E.B., Munz, B., Werner, S., Wehland, J., Birchmeier, C., Birchmeier, W.
  
• (2007) RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T- cell-receptor-mediated integrin activation. Mol. Cell. Biol., 27(11), 4070-4081
  Menasche, G., Kliche, S., Chen, E.J., Stradal, T.E.B., Schraven, B., Koretzky, G.
  
• (2009) IRSp53 links Tir to EspFU/N-WASP-mediated actin assembly in EHEC pedestal formation. Cell Host Microbe, 5, 244-258
  Weiss, S.M., Ladwein, M., Schmidt, D., Ehinger, J., Lommel, S., Städing, K., Beutling, U., Disanza, A., Frank, R., Jänsch, L., Scita, G., Gunzer, F., Rottner, K. & Stradal, T.E.B.
  
• (2009). Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLOS Genet., 5(10), e1000675
  Giuliani, C., Troglio, F., Zucconi, A., Malabarba, G.M., Stradal, T.E.B., Bai, Z., Cassata, G., Confalonieri, S., Chen, E., Hardin J.D., Soto M.C., Grant B.D., Scita, G.