Rolle von beta1-Integrinen für die Lokalisation und Funktion membran-assoziierter Signalmoleküle und Ionenkanäle (Role of beta1-integrins for localization and function of membrane-associated signaling molecules and ion channels)

• Antragsteller: Professor Dr. Klaus Addicks
• Fachliche Zuordnung: Dermatologie
• Förderung: Förderung von 2000 bis 2003
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5250638

Aim of the present proposal is the elucidation of the role of ß1-integrins in mediating signal transduction between hetahelical membrane receptors and coupled downstream target proteins such as ion channels. The key finding underlying our working hypothesis is that in ß1-intgrin deficient embryonic stem cel-derived cardiomyocytes, modulation of L-type Ca2+ channels as well as activation of the acetylcholine activated K+ current via the M2 cholinoceptors is absent. Preliminary experiments indicate that this selective signaling defect occurs at the G-protein level. This suggests a novel central role of integrins in membrane delimited signal transduction processes. With an array of different techniques the molecular mechanism responsible for this defect will be investigated.

• DFG-Verfahren: Schwerpunktprogramme
• Teilprojekt zu: SPP 1086: Genetische und molekulare Analyse von Basalmembranen und Basalmembranverankerung
• Beteiligte Person: Professor Dr. Jürgen Hescheler