Rolle von beta1-Integrinen für die Lokalisation und Funktion membran-assoziierter Signalmoleküle und Ionenkanäle (Role of beta1-integrins for localization and function of membrane-associated signaling molecules and ion channels)

• Applicant: Professor Dr. Klaus Addicks
• Subject Area: Dermatology
• Term: from 2000 to 2003
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5250638

Aim of the present proposal is the elucidation of the role of ß1-integrins in mediating signal transduction between hetahelical membrane receptors and coupled downstream target proteins such as ion channels. The key finding underlying our working hypothesis is that in ß1-intgrin deficient embryonic stem cel-derived cardiomyocytes, modulation of L-type Ca2+ channels as well as activation of the acetylcholine activated K+ current via the M2 cholinoceptors is absent. Preliminary experiments indicate that this selective signaling defect occurs at the G-protein level. This suggests a novel central role of integrins in membrane delimited signal transduction processes. With an array of different techniques the molecular mechanism responsible for this defect will be investigated.

• DFG Programme: Priority Programmes
• Subproject of: SPP 1086: Genetic and Molecular Analysis of Basement Membranes and Basement Membrane Anchorage
• Participating Person: Professor Dr. Jürgen Hescheler