Paracrine and endocrine communication in the renal tubulointerstitium (C03)

• Subject Area: Anatomy and Physiology ; Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

Hormones, autacoids, and signaling metabolites are important determinants of intrarenal communication between different cell types and allow adaptation of one compartment to functional changes in another. Here, we will explore two pathways: i) the pathophysiological role of acetylcholinesterase in collecting ducts and ii) the relationship of interstitial renin and how tubular, interstitial, and juxtaglomerular renin interact in health and disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Frank Schweda