Project Details
Projekt
Urinary vesicles as signal carriers and markers of kidney function development (B02)
Subject Area
Anatomy and Physiology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993
B2 will address three specific aims. We will (i) establish new prognostic biomarkers in urinary vesicles to detect and predict early changes in renal function (vesicular albumin and vesicular podocalyxin), (ii) identify additional tagging proteins in urinary vesicles to gain insights into the types and state of the originating cells, and (iii) clarify the role of extracellular vesicles for intra-renal communication pathways. We will use a broad array of in vivo and in vitro methods and will exploit data from large population-based study groups, taking advantage of the joint expertise on the two PIs in renal (patho-) physiology and epidemiology/statistics, respectively.
DFG Programme
CRC/Transregios
Subproject of
TRR 374:
Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
Applicant Institution
Universität Regensburg
Project Heads
Professor Dr. Hayo Castrop; Professorin Dr. Iris M. Heid
