The role of Lipoprotein Receptor-Related Protein 1 (LRP1) in acute kidney injur (A08*)

• Subject Area: Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

LRP1 is an ubiquitously expressed membrane receptor that is involved in Wnt/β-catenin signaling and in cholesterol metabolism but also in modulation of immune cells. These mechanisms are all involved in the pathogenesis of acute kidney injury (AKI). Our preliminary experiments suggest LRP1 agonism as a plausible nephroprotective therapeutic approach corresponding to published data in myocardial infarct treatment. Thus, we will investigate the role of LRP1 in AKI as an experimental fundament for a clinical study.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Dr. Tilman Jobst-Schwan; Professor Dr. Mario Schiffer