Impact of CCR4 ligands on tissue Treg cells in islet autoimmunity (B02)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 490846870

Type I diabetes is characterized by a breakdown of local self-tolerance with Foxp3+ regulatory T (Treg) cells being crucial cellular mediators. The chemokines CCL22 and CCL17 are important mediators of T cell trafficking with anti- or pro-inflammatory properties respectively. We aim to analyze the impact of CCL22 and CCL17 on Treg cell induction, stability and function in the setting of islet autoimmunity. Specifically, we will make use of gain- and loss-of-function mouse models for components of the CCR4-CCL22/CCL17 axis for in depth analysis of Treg cell phenotypes. These studies will provide insights into the impact of CCR4 ligands on Treg cells and their relevance for T1D development.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 355: Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. David Anz; Dr. Isabelle Serr