Regulation des nukleären Transports ausgewählter Transkriptionsfaktoren durch die verschiedenen Importin alpha-Proteine

• Antragsteller: Dr. Reinhard Depping; Privatdozent Dr. Matthias Köhler
• Fachliche Zuordnung: Nephrologie
• Förderung: Förderung von 1998 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5147852

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Adenoviral E1A protein nuclear import is preferentially mediated by importin a3 in vitro. Virology 289: 186-191, 2001
  Köhler M, Görlich D, Hartmann E, and Franke J
  
• Increased Importin a Protein-Expression in Diabetic Nephropathy. Kidney Int. 60: 2263-2273, 2001
  Köhler M, Buchwalow IB, Alexander G, Christiansen M, Shagdarsuren E, Samoilova V, Hartmann E, Meervala EMA, and Haller H
  
• Differential expression of classical nuclear transport factors during cellular proliferation and differentiation. Cell. Physiol. Biochem. 12: 335-344, 2002
  Köhler M, Fiebeler A, Hartwig M, Thiel S, Prehn S, Kettritz R, Luft FC, and Hartmann E
  
• Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 40: 1095-1104, 2003
  Hanz S, Perlson E, Willis D, Zheng J, Massarwa R, Huerta JJ, Koltzenburg M, Köhler M, Minnen J, Twiss, JF, and Fainzilber M
  
• Importin a nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. J. Biol. Chem. 278: 28193-28200, 2003
  Melen K, Fagerlund R, Franke J, Köhler M, Kinnunen L, and Julkunen I
  
• AMP-activated protein kinaseregulated phosphorylation and acetylation of importin a1. J. Biol. Chem. 279: 48376-48388, 2004
  Wang W, Yang X, Kawai T, López de Silanes I, Mazan-Mamczarz K, Chen P, Chook Y, Quensel C, Köhler M, Gorospe M
  
• In vivo analysis of importin a proteins reveals cellular proliferation inhibition and substrate specificity. Mol. Cell. Biol. 24: 10246-10255, 2004
  Quensel C, Friedrich B, Sommer T, Hartmann E, and Köhler M
  
• NF-kB is imported into the nucleus by importin a3 and importin a4. J. Biol. Chem. 208: 15924- 15951,2005
  Fagerlund R, Kinnunen L, Köhler M, Julkunen I, and Melen K
  
• Nuclear localization signal and protein context both mediate importin a specificity of nuclear import substrates. Mol. Cell. Biol. 26: 8697-8709, 2006
  Friedrich B, Quensel C, Sommer T, Hartmann E, and Köhler M
  
• Normal brain development in importin a5 deficient mice. Nature Cell Biol. 9: 1337-1338, 2007
  Shmidt T, Hampich F, Ridders M, Schultrich S, Hans VH, Tenner K, Vilianovich L, Oadri F, Alenina N, Hartmann E, Köhler M, Bader M
  
• Topoiosmerase II binds importin a isoforms and exportin/CRMI but does not shuttle between the nucleus and cytoplasm in proliferating cells. Exp. Cell Res. 313:627-637,2007
  Mirski SEL, Sparks KE, Friedrich B, Köhler M, Mo YY, Beck WT, and Cole SPC
  
• A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells. BBA - Molecular Cell Research 1783:11613-1622,2008
  Gerstung von Brandenstein M, Abety AN, Depping R, Roth T, Köhler M, Dienes H-P, Preis JWU
  
• Nuclear translocation of hypoxia-inducible factors (HIFs): Involvement of the classical importin a/ß pathway. BBA - Molecular Cell Research. 2008 Mar;1783(3):394-404
  Depping R., Steinhoff, A., Schindler, S, Friedrich, B., Fageriund, R., Metzen, E, Hartmann, E., Köhler, M.
  
• Seizures increase Importin-ß1 Expression in NG2+ Cells in the Rat Hippocampus. Journal of Neuroscience Research 87: 636-643, 2009
  Brilli E, Scali M, Casarosa S, Köhler M, Bozzi Y